Metabolic health during a randomized controlled lifestyle intervention in women with PCOS. Issue 1 (30th November 2021)

• Record Type: Journal Article
• Authors: Dietz de Loos, Alexandra; Jiskoot, Geranne; Beerthuizen, Annemerle; Busschbach, Jan; Laven, Joop
• Is Part Of: European journal of endocrinology. Volume 186:Issue 1(2022)
• Page Start: 53
• Page End: 64
• Publication Date: 2021-11-30
• Subjects: Endocrinology -- Periodicals; 616.4005
• DOI: 10.1530/EJE-21-0669
• Languages: English
• ISSNs: 0804-4643

Abstract

Abstract: Context: Women with polycystic ovary syndrome (PCOS) have an increased risk of metabolic syndrome (MetS). Both PCOS and MetS are associated with excess weight. Objective: To examine the effect of a three-component lifestyle intervention (LSI) with or without short message service (SMS+ or SMS−, respectively) on the prevalence and severity of MetS and metabolic parameters, compared to care as usual (CAU). Design: Randomized controlled trial. Methods: Women diagnosed with PCOS and a BMI >25 kg/m 2 ( n = 183) were either assigned to a 1-year three-component (cognitive behavioural therapy, diet, and exercise) LSI, with or without SMS support, or to CAU which provided weight-loss advice only. Main outcome measures included changes in the prevalence of MetS, the continuous MetS severity z-score (cMetS z-score), metabolic parameters, and the impact of weight loss. Results: After 1 year, the decrease in the cMetS z-score was greater in the SMS+ group than the CAU group (−0.39, P = 0.015). The prevalence of MetS changed with −21.6% ( P = 0.037), −16.5% ( P = 0.190), and +7.0% ( P = 0.509) in both LSI groups and CAU group, respectively. A post hoc analysis for both LSI groups combined vs CAU resulted in a MetS difference of −25.9% ( P = 0.046). Moreover, weight loss per se resulted in significantly favourable effects on all metabolic parameters. Conclusions: This three-component LSI was more successful in improving metabolic health compared to CAU. Therefore, we recommend this intervention to women with PCOS and excess weight, provided that a clinically relevant weight loss is being pursued.