Timing of Kidney Clamping and Deceased Donor Kidney Transplant Outcomes. Issue 11 (November 2021)

• Record Type: Journal Article
• Authors: Ville, Simon; Lorent, Marine; Kerleau, Clarisse; Asberg, Anders; Legendre, Christophe; Morelon, Emmanuel; Buron, Fanny; Garrigue, Valérie; Le Quintrec, Moglie; Girerd, Sophie; Ladrière, Marc; Albano, Laetitia; Sicard, Antoine; Glotz, Denis; Lefaucheur, Carmen; Branchereau, Julien; Jacobi, David; Giral, Magali
• Other Names: Reisæter Anna V. author non-byline.; Line Pål-Dag author non-byline.; Åsberg Anders author non-byline.; Blancho Gilles author non-byline.; Branchereau Julien author non-byline.; Cantarovich Diego author non-byline.; Chapelet Agnès author non-byline.; Dantal Jacques author non-byline.; Deltombe Clément author non-byline.; Figueres Lucile author non-byline.; Garandeau Claire author non-byline.; Giral Magali author non-byline.; Gourraud-Vercel Caroline author non-byline.; Hourmant Maryvonne author non-byline.; Karam Georges author non-byline.; Kerleau Clarisse author non-byline.; Meurette Aurélie author non-byline.; Ville Simon author non-byline.; Kandell Christine author non-byline.; Moreau Anne author non-byline.; Renaudin Karine author non-byline.; Delbos Florent author non-byline.; Walencik Alexandre author non-byline.; Devis Anne author non-byline.; Masset Christophe author non-byline.; Kervella Delphine author non-byline.; Amrouche Lucile author non-byline.; Anglicheau Dany author non-byline.; Aubert Olivier author non-byline.; Bererhi Lynda author non-byline.; Legendre Christophe author non-byline.; Loupy Alexandre author non-byline.; Martinez Frank author non-byline.; Sberro-Soussan Rébecca author non-byline.; Scemla Anne author non-byline.; Zuber Julien author non-byline.; Méjean Arnaud author non-byline.; Timsit Marc Olivier author non-byline.; Eschwege Pascal author non-byline.; Frimat Luc author non-byline.; Girerd Sophie author non-byline.; Hubert Jacques author non-byline.; Ladriere Marc author non-byline.; Laurain Emmanuelle author non-byline.; Leblanc Louis author non-byline.; Lecoanet Pierre author non-byline.; Lemelle Jean-Louis author non-byline.; Badet Lionel author non-byline.; Brunet Maria author non-byline.; Buron Fanny author non-byline.; Cahen Rémi author non-byline.; Daoud Sameh author non-byline.; Fournie Coralie author non-byline.; Grégoire Arnaud author non-byline.; Koenig Alice author non-byline.; Lévi Charlène author non-byline.; Morelon Emmanuel author non-byline.; Pouteil-Noble Claire author non-byline.; Rimmelé Thomas author non-byline.; Thaunat Olivier author non-byline.; Delmas Sylvie author non-byline.; Le Quintrec Moglie author non-byline.; Pernin Vincent author non-byline.; Serre Jean-Emmanuel author non-byline.; Glotz Denis author non-byline.; Lefaucheur Carmen author non-byline.; Albano Laetitia author non-byline.; Sicard Etienne author non-byline.;
• Is Part Of: Clinical journal of the American Society of Nephrology. Volume 16:Issue 11(2021)
• Page Start: 1704
• Page End: 1714
• Publication Date: 2021-11
• Subjects: cadaver organ transplantation -- delayed graft function -- ischemia-reperfusion -- kidney transplantation -- organ transplant -- constriction -- graft survival -- kidney
• DOI: 10.2215/CJN.03290321
• Languages: English
• ISSNs: 1555-9041

Abstract

Visual Abstract: Abstract : Background and objectives: The fact that metabolism and immune function are regulated by an endogenous molecular clock that generates circadian rhythms suggests that the magnitude of ischemia reperfusion, and subsequent inflammation on kidney transplantation, could be affected by the time of the day. Design, setting, participants, & measurements: We evaluated 5026 individuals who received their first kidney transplant from deceased heart-beating donors. In a cause-specific multivariable analysis, we compared delayed graft function and graft survival according to the time of kidney clamping and declamping. Participants were divided into those clamped between midnight and noon ( ante meridiem [am ] clamping group; 65%) or clamped between noon and midnight ( post meridiem [pm ] clamping group; 35%), and, similarly, those who underwent am declamping (25%) or pm declamping (75%). Results: Delayed graft function occurred among 550 participants (27%) with am clamping and 339 (34%) with pm clamping (adjusted odds ratio, 0.81; 95% confidence interval, 0.67 to 0.98; P =0.03). No significant association was observed between clamping time and overall death-censored graft survival (hazard ratio, 0.92; 95% confidence interval, 0.77 to 1.10; P =0.37). No significant association of declamping time with delayed graft function or graft survival was observed. Conclusions: Clamping between midnight and noon was associated with a lower incidence of delayed graft function, whereas declamping time was not associated with kidney graft outcomes.