Drug-Induced Liver Injury From Initial Dose of Infliximab. Issue 6 (1st June 2015)

• Record Type: Journal Article
• Authors: Cheng, Fong-Kuei F.; Bridges, Edward E.; Betteridge, John D.
• Is Part Of: Military medicine. Volume 180:Issue 6(2015)
• Page Start: e723
• Page End: e724
• Publication Date: 2015-06-01
• Subjects: Surgery, Military -- Societies, etc; Medicine, Military -- Societies, etc; Medicine, Military -- Periodicals; Surgery, Military -- Periodicals; Medicine, Military; Surgery, Military; Military Medicine -- Periodicals; Periodicals; Electronic journals; 616.98023
• DOI: 10.7205/MILMED-D-14-00485
• Languages: English
• ISSNs: 0026-4075

Abstract

ABSTRACT: Acute hepatotoxicity secondary to infliximab can occur with or without autoimmunity. A growing body of infliximab drug-induced liver injury cases without autoantibody formation is emerging. Nearly all other reported cases occur after at least three doses. This suggests infliximab may have a direct cytotoxic effect on the liver. We report a case of drug-induced liver injury resulting after an initial dose of infliximab.