Childcare attendance and risk of childhood acute lymphoblastic leukaemia: A register study based on the Danish childcare database. Issue 9 (6th January 2023)

• Record Type: Journal Article
• Authors: Søegaard, Signe Holst; Rostgaard, Klaus; Kamper‐Jørgensen, Mads; Schmiegelow, Kjeld; Hjalgrim, Henrik
• Is Part Of: International journal of cancer. Volume 152:Issue 9(2023)
• Page Start: 1817
• Page End: 1826
• Publication Date: 2023-01-06
• Subjects: acute lymphoblastic leukaemia -- childcare -- cohort study -- infection -- register‐based study; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.34413
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract: Childhood acute lymphoblastic leukaemia (ALL) is suggested to result from a dysregulated immune response to infections in children with a preleukaemic state. Childcare in early life supposedly may protect against childhood ALL by facilitating sufficient exposure to infections to stimulate and ensure normal maturation of the immune system. We assessed the association between childcare attendance before age 2 years and risk of childhood ALL in a register‐based cohort study, including all children aged 2 to 14 years born in Denmark during 1991 to 2014 with available childcare information recorded in the Danish Childcare Database (n = 1 116 185). Cox regression was used to estimate hazard ratios (HRs) comparing children enrolled in childcare and children not enrolled before age 2 years. Further, we assessed the association according to age at enrolment, type of childcare facility and specific ALL subtypes. During 10 460 811 person‐years of follow‐up, 460 children developed ALL at ages 2 to 14 years. Of these, 57 (12.4%) never attended childcare before age 2 years compared with 10.6% in the total cohort. Compared with homecare, childcare attendance before age 2 years was associated with a statistically non‐significantly, marginally decreased risk of childhood ALL with adjusted HR = 0.87 (95% confidence interval [CI]: 0.65‐1.16). Risk estimates did neither vary statistically significantly by age at enrolment nor by type of childcare facility and also not between childhood ALL subtypes, including frequently prenatally initiated ALL subtypes. Results from this large, nationwide register‐based study provided no evidence that childcare attendance in the first years of life protects against childhood ALL. Abstract : What's new? Childhood acute lymphoblastic leukaemia (ALL) is suggested to result from a dysregulated immune response to infections in children with preleukaemic cells. Previous case‐control studies support that childcare, through extensive early exposure to infections, protects against childhood ALL, but potential biases cannot be excluded. In this large, nationwide register‐based study using administrative data, the authors found no evidence that childcare attendance in the first years of life protects against childhood ALL. Taken at face value, the results suggest that, if at all, immune modulation critical to ALL risk occurs early in the first year of life.