Global incidence of young‐onset dementia: A systematic review and meta‐analysis. Issue 3 (17th June 2022)

• Record Type: Journal Article
• Authors: Hendriks, Stevie; Peetoom, Kirsten; Bakker, Christian; Koopmans, Raymond; van der Flier, Wiesje; Papma, Janne; Verhey, Frans; de Vugt, Marjolein; Köhler, Sebastian
• Is Part Of: Alzheimer's & dementia. Volume 19:Issue 3(2023)
• Page Start: 831
• Page End: 843
• Publication Date: 2022-06-17
• Subjects: incidence -- meta‐analysis -- worldwide -- young‐onset dementia; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.12695
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Reliable data on the incidence rates for young‐onset dementia (YOD) are lacking, but are necessary for research on disease etiology and to raise awareness among health care professionals. Methods: We performed a systematic review and meta‐analysis on population‐based studies on the incidence of YOD, published between January 1, 1990 and February 1, 2022, according to Meta‐analyses of Observational Studies in Epidemiology (MOOSE) guidelines. Data were analyzed using random‐effects meta‐analyses. Results were age‐standardized, and heterogeneity was assessed by subgroup analyses and meta‐regression. Results: Sixty‐one articles were included. Global age‐standardized incidence rates increased from 0.17/100, 000 in age 30 to 34 years, to 5.14/100, 000 in age 60 to 64 years, giving a global total age‐standardized incidence rate of 11 per 100, 000 in age 30 to 64. This corresponds to 370, 000 new YOD cases annually worldwide. Heterogeneity was high and meta‐regression showed geographic location significantly influenced this heterogeneity. Discussion: This meta‐analysis shows the current best estimate of YOD incidence. New prospective cohort studies are needed.