Hyperreflective cystoid spaces in diabetic macular oedema: prevalence and clinical implications. Issue 4 (1st December 2020)

• Record Type: Journal Article
• Authors: Couturier, Aude; Mane, Valerie; Lavia, Carlo Alessandro; Tadayoni, Ramin
• Is Part Of: British journal of ophthalmology. Volume 106:Issue 4(2022)
• Page Start: 540
• Page End: 546
• Publication Date: 2020-12-01
• Subjects: retina -- imaging; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjophthalmol-2020-317191
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Aims: To analyse the prevalence and evolution of hyper-reflective cystoid spaces with decorrelation signal detected using optical coherence tomography angiography (OCTA) in diabetic macular oedema (DMO). Methods: A retrospective study of consecutive eyes with DMO imaged using OCTA over a 1-year period was conducted. All eyes with hyper-reflective cystoid spaces at baseline and at least 3 months of follow-up were included in a longitudinal analysis. Results: The prevalence of hyperreflective cystoid spaces with decorrelation signal was of 37% (61/165) in DMO eyes. Hyperreflective foci within hyperreflective cystoid spaces were observed in 85% of eyes. The longitudinal study included 33 eyes (10 observed and 23 treated with intravitreal anti-vascular endothelial growth factor), with a median follow-up of 15 months. The hyperreflective cystoid spaces resolved in 85% of eyes. The mean best-corrected visual acuity remained stable during the follow-up, even in the eyes achieving a resolution of the hyperreflective cystoid spaces. Hard exudates appeared in the area of resolved hyperreflective cystoid spaces in 33% of eyes. Conclusion: Hyperreflective cystoid spaces detected by OCTA affected more than one-third of the DMO eyes. Their disappearance was not associated with any functional improvement and led to the formation of new hard exudate deposits in about one-third of the eyes.