Mechanisms of mindfulness in patients with migraine: Results of a qualitative study. Issue 3 (28th February 2023)

• Record Type: Journal Article
• Authors: Estave, Paige M.; Margol, Caitlyn; Beeghly, Summerlyn; Anderson, Reid; Shakir, Mariam; Coffield, Alexandra; Byrnes, Julia; O'Connell, Nathaniel; Seng, Elizabeth; Gardiner, Paula; Wells, Rebecca Erwin
• Is Part Of: Headache. Volume 63:Issue 3(2023)
• Page Start: 390
• Page End: 409
• Publication Date: 2023-02-28
• Subjects: headache -- mechanisms -- migraine -- mindfulness -- mindfulness‐based stress reduction -- qualitative; Headache -- Periodicals; Headache -- Periodicals; 616.8491
• DOI: 10.1111/head.14481
• Languages: English
• ISSNs: 0017-8748

Abstract

Abstract: Objective: To understand the mechanisms of mindfulness' impact on migraine. Background: Promising mindfulness research demonstrates potential benefit in migraine, but no data‐driven model exists from the lived experiences of patients that explains the mechanisms of mindfulness in migraine. Methods: Semi‐structured qualitative interviews were conducted with adults with migraine who participated in two mindfulness‐based stress reduction (MBSR) clinical trials ( n = 43). Interviews were audio‐recorded, transcribed, and summarized into a framework matrix with development of a master codebook. Constructivist grounded theory approach was used to identify themes/subthemes. Results: Participants who learned mindfulness techniques through MBSR experienced altered pain perception, altered response to migraine attacks and disease, increased awareness of external and internal experiences, improved overall well‐being, and group benefits. Mindfulness resulted in earlier stress‐body awareness and increased interoceptive awareness resulting in earlier attack recognition, leading to earlier and more effective management. Interictal factors of self‐blame, guilt, and stigma decreased while migraine acceptance, hope, empowerment, self‐efficacy, and self‐compassion increased. Improved emotion regulation resulted in decreased fear of migraine, pain catastrophizing, anticipatory anxiety, and pain reactivity. Although taught as prevention, mindfulness was used both acutely and prophylactically. We created a conceptual model hypothesizing that MBSR skills led to an infusion of mindfulness in daily life, resulting in altered pain perception and experience, ultimately leading to improvement in overall well‐being, which may positively feed back to the infusion of mindfulness in daily life. The therapeutic benefit of learning mindfulness in a group setting may moderate these effects. Conclusions: This study identified several new potential mechanisms of mindfulness' effect on migraine. After learning MBSR skills, participants reported altered pain and migraine perception and experiences. Increased stress‐body and interoceptive awareness resulted in earlier migraine awareness and treatment. Mindfulness may target important interictal factors that affect disease burden such as fear of migraine, pain catastrophizing, and anticipatory anxiety. This is the first data‐driven study to help elucidate the mechanisms of mindfulness on migraine from patient voices and can help direct future research endeavors.