Acute and sustained increase in endothelial biomarkers in COVID-19. Issue 4 (4th October 2021)

• Record Type: Journal Article
• Authors: Méndez, Raúl; González-Jiménez, Paula; Latorre, Ana; Piqueras, Mónica; Bouzas, Leyre; Yépez, Katheryn; Ferrando, Ana; Zaldívar-Olmeda, Enrique; Moscardó, Antonio; Alonso, Ricardo; Reyes, Soledad; Menéndez, Rosario
• Is Part Of: Thorax. Volume 77:Issue 4(2022)
• Page Start: 400
• Page End: 403
• Publication Date: 2021-10-04
• Subjects: COVID-19 -- respiratory infection -- viral infection -- pneumonia; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2020-216797
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Endothelial injury is related to poor outcomes in respiratory infections yet little is known in relation to COVID-19. Performing a longitudinal analysis (on emergency department admission and post-hospitalisation follow-up), we evaluated endothelial damage via surrogate systemic endothelial biomarkers, that is, proadrenomedullin (proADM) and proendothelin, in patients with COVID-19. Higher proADM and/or proendothelin levels at baseline were associated with the most severe episodes and intensive care unit admission when compared with ward-admitted individuals and outpatients. Elevated levels of proADM or proendothelin at day 1 were associated with in-hospital mortality. High levels maintained after discharge were associated with reduced diffusing capacity.