Shared functional network abnormality in patients with temporal lobe epilepsy and their siblings. (17th January 2023)

• Record Type: Journal Article
• Authors: Wang, Kangrun; Xie, Fangfang; Liu, Chaorong; Wang, Ge; Zhang, Min; He, Jialinzi; Tan, Langzi; Tang, Haiyun; Chen, Fenghua; Xiao, Bo; Song, Yanmin; Long, Lili
• Is Part Of: CNS neuroscience & therapeutics. Volume 29:Number 4(2023)
• Page Start: 1109
• Page End: 1119
• Publication Date: 2023-01-17
• Subjects: endophenotype -- functional magnetic resonance imaging -- graph theory -- independent component analysis -- temporal lobe epilepsy; Neuropharmacology -- Periodicals; Central nervous system -- Diseases -- Effect of drugs on -- Periodicals; 612.8
• DOI: 10.1111/cns.14087
• Languages: English
• ISSNs: 1755-5930

Abstract

Abstract: Aim: Temporal lobe epilepsy is a neurological network disease in which genetics played a greater role than previously appreciated. This study aimed to explore shared functional network abnormalities in patients with sporadic temporal lobe epilepsy and their unaffected siblings. Methods: Fifty‐eight patients with sporadic temporal lobe epilepsy, 13 unaffected siblings, and 30 healthy controls participated in this cross‐sectional study. We examined the task‐based whole‐brain functional network topology and the effective functional connectivity between networks identified by group‐independent component analysis. Results: We observed increased global efficiency, decreased clustering coefficiency, and decreased small‐worldness in patients and siblings ( p < 0.05, false discovery rate‐corrected). The effective network connectivity from the ventral attention network to the limbic system was impaired ( p < 0.001, false discovery rate‐corrected). These features had higher prevalence in unaffected siblings than in normal population and was not correlated with disease burden. In addition, topological abnormalities had a high intraclass correlation between patients and their siblings. Conclusion: Patients with temporal lobe epilepsy and their unaffected siblings showed shared topological functional disturbance and the effective functional network connectivity impairment. These abnormalities may contribute to the pathogenesis that promotes the susceptibility of seizures and language decline in temporal lobe epilepsy. Abstract : Patients with temporal lobe epilepsy and their unaffected siblings showed shared topological disturbance of whole‐brain functional network and the effective functional network connectivity impairment between the ventral attention network and the limbic system. These abnormalities were potential endophenotype candidates and may contribute to the pathogenesis that promotes the susceptibility of seizures and language decline in temporal lobe epilepsy.