Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study. Issue 4 (21st October 2021)

• Record Type: Journal Article
• Authors: Nathan, Nadia; Montagne, Marie-Emeline; Macchi, Odile; Rosental, Paul-André; Chauveau, Simon; Jeny, Florence; Sesé, Lucile; Abou Taam, Rola; Brocvielle, Manon; Brouard, Jacques; Catinon, Mickaël; Chapelon-Abric, Catherine; Cohen-Aubart, Fleur; Delacourt, Christophe; Delestrain, Céline; Deschildre, Antoine; Dossier, Antoine; Epaud, Ralph; Haroche, Julien; Houdouin, Véronique; Israel-Biet, Dominique; Juvin, Karine; Le Jeune, Sylvain; Lionnet, Francois; Meinzer, Ulrich; Mittaine, Marie; Nunes, Hilario; Mattioni, Sarah; Naccache, Jean-Marc; Odièvre, Marie-Hélène; Vincent, Michel; Clement, Annick; Valeyre, Dominique; Cavalin, Catherine;
• Is Part Of: Thorax. Volume 77:Issue 4(2022)
• Page Start: 404
• Page End: 407
• Publication Date: 2021-10-21
• Subjects: sarcoidosis -- paediatric interstitial lung disease -- occupational lung disease -- rare lung diseases; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2021-217870
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients' indirect exposure to inorganic particles, through coresidents' occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5–7) vs 0.5 (0–2), p=0.003 and 1 (0–2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis.