Modified Erasmus GBS Respiratory Insufficiency Score: a simplified clinical tool to predict the risk of mechanical ventilation in Guillain-Barré syndrome. Issue 4 (25th November 2022)

• Record Type: Journal Article
• Authors: Luijten, Linda W G; Doets, Alex Y; Arends, Samuel; Dimachkie, Mazen M; Gorson, Kenneth C; Islam, Badrul; Kolb, Noah A; Kusunoki, Susumu; Papri, Nowshin; Waheed, Waqar; Walgaard, Christa; Yamagishi, Yuko; Lingsma, Hester; Jacobs, Bart C
• Other Names: author non-byline.; Hughes Richard A C author non-byline.; Cornblath David R author non-byline.; Hartung Hans-Peter author non-byline.; Doorn Pieter A van author non-byline.; Willison Hugh J author non-byline.; Berg Bianca van den author non-byline.; Verboon Christine author non-byline.; Roodbol Joyce author non-byline.; Leonhard Sonja E author non-byline.; Thomma Robin CM author non-byline.; Koning Laura C de author non-byline.; Mandarakas Melissa author non-byline.; Woerkom Marieke van author non-byline.; Reddel Stephen W author non-byline.; Islam Zhahirul author non-byline.; Mohammad Quazi Deen author non-byline.; Bergh Peter van den author non-byline.; Feasby Tom E author non-byline.; Wang Yuzhong author non-byline.; Harbo Thomas author non-byline.; Péréon Yann author non-byline.; Lehmann Helmar C author non-byline.; Dardiotis Efthimios author non-byline.; Nobile-Orazio Eduardo author non-byline.; Shahrizaila Nortina author non-byline.; Bateman Kathleen author non-byline.; Querol Luis author non-byline.; Ripellino Paolo author non-byline.; Hsieh Sung-Tsang author non-byline.; Chavada Govindsinh author non-byline.; Davidson Amy author non-byline.; Addington James M author non-byline.; Ajroud-Driss Senda author non-byline.; Alessandro Lucas author non-byline.; Andersen Henning author non-byline.; Antonini Giovanni author non-byline.; Attarian Shahram author non-byline.; Badrising Umesh A author non-byline.; Barroso Fabio A author non-byline.; Bella Isabelita R author non-byline.; Benedetti Luana author non-byline.; Bertorini Tulio E author non-byline.; Bhavaraju-Sanka Ratna author non-byline.; Bianco Mariangela author non-byline.; Brannagan Thomas H author non-byline.; Briani Chiara author non-byline.; Bürmann Jan author non-byline.; Busby Mark author non-byline.; Butterworth Stephen author non-byline.; Casasnovas Carlos author non-byline.; Cavaletti Guido author non-byline.; Chao Chi-Chao author non-byline.; Chen Shan author non-byline.; Claeys Kristl G author non-byline.; Conti Maria Eugenia author non-byline.; Cosgrove Jeremy S author non-byline.; Dalakas Marinos C author non-byline.; Cour Charlotte Dornonville de la author non-byline.; Echaniz-Laguna Andoni author non-byline.; Eftimov Filip author non-byline.; Faber Catharina G author non-byline.; Fazio Raffaella author non-byline.; Fehmi Janev author non-byline.; Fokke Chris author non-byline.; Fujioka Toshiki author non-byline.; Fulgenzi Ernesto A author non-byline.; Galassi Giuliana author non-byline.; García-Sobrino T author non-byline.; Garssen Marcel PJ author non-byline.; Gijsbers Cees J author non-byline.; Gilchrist James M author non-byline.; Jacobus Gilhuis H author non-byline.; Goldstein Jonathan M author non-byline.; Goyal Namita A author non-byline.; Granit Volkan author non-byline.; Grisanti Stefano G author non-byline.; Gutiérrez-Gutiérrez Gerardo author non-byline.; Gutmann Lauri author non-byline.; Hadden Robert DM author non-byline.; Holbech Jakob V author non-byline.; Holt James KL author non-byline.; Htut Min author non-byline.; Jellema Korné author non-byline.; Pascual Ivonne Jericó author non-byline.; Jimeno-Montero María C author non-byline.; Kaida Kenichi author non-byline.; Karafiath Summer author non-byline.; Katzberg Hans D author non-byline.; Kerkhoff Henk author non-byline.; Khoshnoodi Mohammad Ali M author non-byline.; Kiers Lynette author non-byline.; Kleyweg Ruud P author non-byline.; Kokubun Norito author non-byline.; Kramers Hans author non-byline.; Kuitwaard Krista author non-byline.; Kuwabara Satoshi author non-byline.; Kwan Justin Y author non-byline.; Ladha Shafeeq S author non-byline.; Lassen Lisbeth Landschoff author non-byline.; Lawson Victoria author non-byline.; Pan Edward Lee author non-byline.; Cejas Luciana León author non-byline.; Marchesoni Cintia Lorena author non-byline.; Lunn Michael P T author non-byline.; Magot Armelle author non-byline.; Manji Hadi author non-byline.; Marfia Gerola A author non-byline.; Márquez-Infante Celedonio author non-byline.; Aguilar Lorena Martin author non-byline.; Martinez-Hernandez Eugenia author non-byline.; Mataluni Giorgia author non-byline.; Mattiazzi Marcelo G author non-byline.; McDermott Chris J author non-byline.; Meekins Gregg D author non-byline.; Miller James AL author non-byline.; Monges Maria Soledad author non-byline.; Tassa Germán Morís de la author non-byline.; Mozzoni Julieta author non-byline.; Nascimbene Caterina author non-byline.; Nowak Richard J author non-byline.; Osei-Bonsu Michael author non-byline.; Pardo Julio author non-byline.; Pascuzzi Robert M author non-byline.; Prada Valeria author non-byline.; Pulley Michael T author non-byline.; Rinaldi Simon author non-byline.; Roberts Rhys C author non-byline.; Rojas-Marcos Iñigo author non-byline.; Rudnicki Stacy A author non-byline.; Sachs George M author non-byline.; Samijn Johnny PA author non-byline.; Santoro Lucio author non-byline.; Schenone Angelo author non-byline.; Schwindling Lenka author non-byline.; Tous Maria J Sedano author non-byline.; Sheikh Kazim A author non-byline.; Silvestri Nicholas J author non-byline.; Sindrup Soren H author non-byline.; Sommer Claudia L author non-byline.; Stein Beth author non-byline.; Stino Amro M author non-byline.; Tan Cheng-Yin author non-byline.; Tankisi Hatice author non-byline.; Twydell Paul T author non-byline.; Damme Philip Van author non-byline.; van der Kooi Anneke J author non-byline.; Ree Taco C van der author non-byline.; van Dijk Gert W author non-byline.; Koningsveld Rinske van author non-byline.; Varrato Jay D author non-byline.; Vélez-Santamaría Valentina author non-byline.; Vermeij Frederique H author non-byline.; Verschuuren Jan JGM author non-byline.; Visser Leo H author non-byline.; Vytopil Michal V author non-byline.; Wirtz Paul W author non-byline.; Zhang Guorong author non-byline.; Zhou Lan author non-byline.; Zivkovic Sasha author non-byline.;
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 94:Issue 4(2023)
• Page Start: 300
• Page End: 308
• Publication Date: 2022-11-25
• Subjects: guillain-barre syndrome -- clinical neurology -- intensive care -- neuromuscular; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2022-329937
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Background: This study aimed to determine the clinical and diagnostic factors associated with mechanical ventilation (MV) in Guillain-Barré syndrome (GBS) and to simplify the existing Erasmus GBS Respiratory Insufficiency Score (EGRIS) for predicting the risk of MV. Methods: Data from the first 1500 patients included in the prospective International GBS Outcome Study (IGOS) were used. Patients were included across five continents. Patients <6 years and patients from Bangladesh were excluded. Univariable logistic and multivariable Cox regression were used to determine which prespecified clinical and diagnostic characteristics were associated with MV and to predict the risk of MV at multiple time points during disease course. Results: 1133 (76%) patients met the study criteria. Independent predictors of MV were a shorter time from onset of weakness until admission, the presence of bulbar palsy and weakness of neck flexion and hip flexion. The modified EGRIS (mEGRIS) was based on these factors and accurately predicts the risk of MV with an area under the curve (AUC) of 0.84 (0.80–0.88). We internally validated the model within the full IGOS cohort and within separate regional subgroups, which showed AUC values of 0.83 (0.81–0.88) and 0.85 (0.72–0.98), respectively. Conclusions: The mEGRIS is a simple and accurate tool for predicting the risk of MV in GBS. Compared with the original model, the mEGRIS requires less information for predictions with equal accuracy, can be used to predict MV at multiple time points and is also applicable in less severely affected patients and GBS variants. Model performance was consistent across different regions.