Synthesis and evaluation of 1, 5-dithialaminaribiose and -triose tetravalent constructs. (March 2023)

• Record Type: Journal Article
• Authors: Ahiadorme, Daniil; Ande, Chennaiah; Fernandez-Botran, Rafael; Crich, David
• Is Part Of: Carbohydrate research. Volume 525(2023)
• Publication Date: 2023-03
• Subjects: Oligomers -- Thiasugars -- Immunology -- Multivalency; Carbohydrates -- Periodicals; Chemistry, Organic -- Periodicals; Biochemistry -- Periodicals; Carbohydrates -- Periodicals; Chimie organique -- Périodiques; Glucides -- Périodiques; Biochemistry; Carbohydrates; Chemistry, Organic; Periodicals; Electronic journals; 507.78
• DOI: 10.1016/j.carres.2023.108781
• Languages: English
• ISSNs: 0008-6215

Abstract

Abstract: We report the synthesis of novel tetravalent glucoclusters containing 1, 5-dithia mimetics of laminaribiose and triose. The new constructs were evaluated for their ability to inhibit anti-CR3 fluorescent staining of human neutrophils, for which they showed moderate affinity. Evaluation of the synthesized glycoclusters for their ability to inhibit anti-Dectin-1 fluorescent staining of mouse macrophages revealed little to no affinity for Dectin-1. Graphical abstract: Image 1 Highlights: Easily accessible tetracarboxyl multivalent core. Novel dithiasugar-based epitope. Novel multivalent glucoclusters. Significant affinity of synthesized glucoclusters for CR3.