Innate Immunity and SARS-CoV-2 Vaccine Response in Hemodialysis Patients. Issue 10 (27th October 2022)

• Record Type: Journal Article
• Authors: Valentini, Nicolas; Marchitto, Lorie; Raymond, Maxime; Goyette, Guillaume; Kaufmann, Daniel E.; Finzi, Andrés; Suri, Rita S.; Lamarche, Caroline
• Is Part Of: Kidney360. Volume 3:Issue 10(2022)
• Page Start: 1763
• Page End: 1768
• Publication Date: 2022-10-27
• Subjects: chronic kidney disease -- basic science -- COVID-19 -- dendritic cell -- immune response -- innate immunity -- monocyte -- mRNA vaccine -- SARS-CoV-2; 616.61
• DOI: 10.34067/KID.0002542022
• Languages: English
• ISSNs: 2641-7650

Abstract

Key Points: Patients receiving hemodialysis (HD) have more inflammatory monocytes and less plasmacytoid dendritic cells (DCs) compared with healthy controls. Patients on HD who have a poor antibody response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine had fewer monocyte-derived DCs and conventional DCs compared with good responders. The defects in antigen presentation might be possible therapeutic targets to increase vaccine efficacy in HD patients.