Magnetization‐prepared spoiled gradient‐echo snapshot imaging for efficient measurement of R2‐R1ρ in knee cartilage. Issue 2 (30th September 2021)

• Record Type: Journal Article
• Authors: Han, Misung; Tibrewala, Radhika; Bahroos, Emma; Pedoia, Valentina; Majumdar, Sharmila
• Is Part Of: Magnetic resonance in medicine. Volume 87:Issue 2(2022)
• Page Start: 733
• Page End: 745
• Publication Date: 2021-09-30
• Subjects: knee cartilage -- Osteoarthritis -- quantitative MRI -- R2‐R1ρ -- relaxation; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.29024
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: To validate the potential of quantifying R2 ‐R1ρ using one pair of signals with T1ρ preparation and T2 preparation incorporated to magnetization‐prepared angle‐modulated partitioned k‐space spoiled gradient‐echo snapshots (MAPSS) acquisition and to find an optimal preparation time (Tprep ) for in vivo knee MRI. Methods: Bloch equation simulations were first performed to assess the accuracy of quantifying R2 ‐R1ρ using T1ρ ‐ and T2 ‐prepared signals with an equivalent Tprep . For validation of this technique in comparison to the conventional approach that calculates R2 ‐R1ρ after estimating both T2 and T1ρ, phantom experiments and in vivo validation with five healthy subjects and five osteoarthritis patients were performed at a clinical 3T scanner. Results: Bloch equation simulations demonstrated that the accuracy of this efficient R2 ‐R1ρ quantification method and the optimal Tprep can be affected by image signal‐to‐noise ratio (SNR) and tissue relaxation times, but quantification can be closest to the reference with an around 25 ms Tprep for knee cartilage. Phantom experiments demonstrated that the proposed method can depict R2 ‐R1ρ changes with agarose gel concentration. With in vivo data, significant correlation was observed between cartilage R2 ‐R1ρ measured from the conventional and the proposed methods, and a Tprep of 25.6 ms provided the most agreement by Bland‐Altman analysis. R2 ‐R1ρ was significantly lower in patients than in healthy subjects for most cartilage compartments. Conclusion: As a potential biomarker to indicate cartilage degeneration, R2 ‐R1ρ can be efficiently measured using one pair of T1ρ ‐prepared and T2 ‐prepared signals with an optimal Tprep considering cartilage relaxation times and image SNR.