Impact of donor ferritin testing on iron deficiency prevention and blood availability in France: A cohort simulation study. Issue 1 (25th November 2022) - Richard, Pascale
Abstract: Background and Objectives: Implementing a ferritin testing policy for whole blood (WB) donors may prevent iron deficiency (ID, ferritin <26 ng/mL) and anaemia, but may induce donation losses. As part of a national prevention plan in France, we aimed to estimate its impact on ID, anaemias and WB donations among donors at high risk of ID. Materials and Methods: A micro‐simulation model was developed to evaluate different scenarios compared to the current situation without ferritin testing as a reference scenario. The following scenarios were simulated: a minimum scenario with a 6‐month deferral for donors with absent iron store (AIS, ferritinemia <15 ng/ml), a main scenario with additional delayed invitations for donors with ferritinemia 15–25 ng/ml and a supplementation scenario with additional iron supplementation for 50% of the donors with AIS. Results: In the main scenario, 52, 699 WB donations per year were estimated to be lost after 1 year (−8%), falling to 27, 687 (−4.7%) after 5 years. IDs and anaemias were reduced by 13.6% and 29.3%, respectively, after 1 year. The supplementation scenario increased the number of prevented IDs and anaemias to 24.1% and 35.4%, respectively, after 1 year, and halved the number of anaemias at 5 years. The latter scenario also had the least impact on the number of donations (−3.2% after 5 years). Conclusion: A ferritin testing policy resulting in delayed donations for ID donors is effective in reducing IDs and anaemias, but significantly impacts the number of donations, thereby posing a self‐sufficiency challenge.