Chemical Biology Approaches to Understanding Neuronal O−GlcNAcylation. Issue 1 (15th November 2022)

• Record Type: Journal Article
• Authors: Huynh, Duc Tan; Boyce, Michael
• Other Names: Kramer Jessica R. guestEditor.; Pratt Matthew R. guestEditor.; Schumann Benjamin guestEditor.
• Is Part Of: Israel journal of chemistry. Volume 63:Issue 1/2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-15
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/ijch.202200071
• Languages: English
• ISSNs: 0021-2148

Abstract

Abstract: O‐linked β‐ N ‐acetylglucosamine (O−GlcNAc) is a ubiquitous post‐translational modification in mammals, decorating thousands of intracellular proteins. O−GlcNAc cycling is an essential regulator of myriad aspects of cell physiology and is dysregulated in numerous human diseases. Notably, O−GlcNAcylation is abundant in the brain and numerous studies have linked aberrant O−GlcNAc signaling to various neurological conditions. However, the complexity of the nervous system and the dynamic nature of protein O−GlcNAcylation have presented challenges for studying of neuronal O−GlcNAcylation. In this context, chemical approaches have been a particularly valuable complement to conventional cellular, biochemical, and genetic methods to understand O−GlcNAc signaling and to develop future therapeutics. Here we review selected recent examples of how chemical tools have empowered efforts to understand and rationally manipulate O−GlcNAcylation in mammalian neurobiology. Abstract :