Enhanced circulating levels of CD3 cells‐derived extracellular vesicles in different forms of pulmonary hypertension. (1st July 2019)

• Record Type: Journal Article
• Authors: Kosanovic, Djuro; Deo, Ujjwal; Gall, Henning; Selvakumar, Balachandar; Herold, Susanne; Weiss, Astrid; Petrovic, Aleksandar; Sydykov, Akylbek; Ghofrani, Hossein Ardeschir; Schermuly, Ralph Theo
• Is Part Of: Pulmonary circulation. Volume 9:Number 3(2019)
• Page Start: 1
• Page End: 4
• Publication Date: 2019-07-01
• Subjects: extracellular vesicles -- pulmonary hypertension -- biomarkers -- T‐cells -- endothelial cells; Pulmonary circulation -- Periodicals; Pulmonary circulation; Electronic journals -- Sciences; Periodicals; 616.24005
• DOI: 10.1177/2045894019864357
• Languages: English
• ISSNs: 2045-8932

Abstract

Abstract : It has been shown previously that increased circulating endothelial cells‐derived extracellular vesicles represent an important pathological attribute of pulmonary hypertension. Although it is a well‐known fact that inflammatory cells may also release extracellular vesicles, and pulmonary hypertension is a disease associated with abnormal inflammation, there is no profound knowledge with regard to the role of inflammatory cells‐derived extracellular vesicles. Therefore, our study demonstrated that circulating levels of extracellular vesicles derived from T‐cells are enhanced in various pulmonary hypertension forms and that endothelial cells‐derived extracellular vesicles may have distinctive profiles in different clinical subgroups of pulmonary hypertension, which still remains as a poorly treatable and life‐threatening disorder.