Dural arteriovenous fistulas in cerebral venous thrombosis: Data from the International Cerebral Venous Thrombosis Consortium. (4th December 2021)

• Record Type: Journal Article
• Authors: Lindgren, Erik; Rentzos, Alexandros; Hiltunen, Sini; Serrano, Fabiola; Heldner, Mirjam R.; Zuurbier, Susanna M.; Silvis, Suzanne M.; Mansour, Maryam; Allingham, William; Punter, Martin N. M.; Giarola, Blake F.; Wells, Jeremy; Sánchez van Kammen, Mayte; Piechowiak, Eike I.; Chiota‐McCollum, Nicole; Garcia‐Esperon, Carlos; Cognard, Christophe; Kleinig, Timothy; Ghiasian, Masoud; Coutinho, Jonathan M.; Arnold, Marcel; Arauz, Antonio; Putaala, Jukka; Jood, Katarina; Tatlisumak, Turgut
• Is Part Of: European journal of neurology. Volume 29:Number 3(2022)
• Page Start: 761
• Page End: 770
• Publication Date: 2021-12-04
• Subjects: cerebral venous thrombosis -- dural arteriovenous fistula -- follow‐up -- long‐term outcome -- stroke; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.15192
• Languages: English
• ISSNs: 1351-5101

Abstract

Abstract: Background and purpose: To explore the prevalence, risk factors, time correlation, characteristics and clinical outcome of dural arteriovenous fistulas (dAVFs) in a cerebral venous thrombosis (CVT) population. Methods: We included patients from the International CVT Consortium registries. Diagnosis of dAVF was confirmed centrally. We assessed the prevalence and risk factors for dAVF among consecutive CVT patients and investigated its impact on clinical outcome using logistic regression analysis. We defined poor outcome as modified Rankin Scale score 3–6 at last follow‐up. Results: dAVF was confirmed in 29/1218 (2.4%) consecutive CVT patients. The median (interquartile range [IQR]) follow‐up time was 8 (5–23) months. Patients with dAVF were older (median [IQR] 53 [44–61] vs. 41 [29–53] years; p < 0.001), more frequently male (69% vs. 33%; p < 0.001), more often had chronic clinical CVT onset (>30 days: 39% vs. 7%; p < 0.001) and sigmoid sinus thrombosis (86% vs. 51%; p < 0.001), and less frequently had parenchymal lesions (31% vs. 55%; p = 0.013) at baseline imaging. Clinical outcome at last follow‐up did not differ between patients with and without dAVF. Additionally, five patients were confirmed with dAVF from non‐consecutive CVT cohorts. Among all patients with CVT and dAVF, 17/34 (50%) had multiple fistulas and 23/34 (68%) had cortical venous drainage. Of 34 patients with dAVF with 36 separate CVT events, 3/36 fistulas (8%) were diagnosed prior to, 20/36 (56%) simultaneously and 13/36 after (36%, median 115 [IQR 38–337] days) diagnosis of CVT. Conclusions: Dural arteriovenous fistulas occur in at least 2% of CVT patients and are associated with chronic CVT onset, older age and male sex. Most CVT‐related dAVFs are detected simultaneously or subsequently to diagnosis of CVT. Abstract : This article describes dural arteriovenous fistulas (dAVFs) among adult patients diagnosed with cerebral venous thrombosis (CVT) included from the International CVT Consortium registries. dAVF was centrally confirmed among 2.4% patients (29/1218) and was most commonly detected simultaneously or subsequently to diagnosis of CVT. Half of the patients with dAVF had multiple fistulas, and fistulas were associated with chronic CVT onset, older age and male sex.