Changing trends in mortality among solid organ transplant recipients hospitalized for COVID‐19 during the course of the pandemic. Issue 1 (7th October 2021)

• Record Type: Journal Article
• Authors: Heldman, Madeleine R.; Kates, Olivia S.; Safa, Kassem; Kotton, Camille N.; Georgia, Sarah J.; Steinbrink, Julie M.; Alexander, Barbara D.; Hemmersbach‐Miller, Marion; Blumberg, Emily A.; Multani, Ashrit; Haydel, Brandy; La Hoz, Ricardo M.; Moni, Lisset; Condor, Yesabeli; Flores, Sandra; Munoz, Carlos G.; Guitierrez, Juan; Diaz, Esther I.; Diaz, Daniela; Vianna, Rodrigo; Guerra, Giselle; Loebe, Matthias; Rakita, Robert M.; Malinis, Maricar; Azar, Marwan M.; Hemmige, Vagish; McCort, Margaret E.; Chaudhry, Zohra S.; Singh, Pooja P.; Hughes Kramer, Kailey; Velioglu, Arzu; Yabu, Julie M.; Morillis, Jose A.; Mehta, Sapna A.; Tanna, Sajal D.; Ison, Michael G.; Derenge, Ariella C.; van Duin, David; Maximin, Adrienne; Gilbert, Carlene; Goldman, Jason D.; Lease, Erika D.; Fisher, Cynthia E.; Limaye, Ajit P.;
• Other Names: De la Cruz Oveimar investigator.; Besharatian Behdad D. investigator.; Crespo Maria investigator.; Tomic Rade investigator.; Sehgal Sameep investigator.; Weisshaar Dana investigator.; Girgis Reda investigator.; Lawrence Cameron investigator.; Nelson Joanna investigator.; Bennett William investigator.; Leandro Jennifer investigator.; Sait Afrah investigator.; Rumore Amy investigator.; West Patricia investigator.; Jeng Amy investigator.; Bajrovic Valida investigator.; Bilgili Erin P. investigator.; Anderson‐Haag Tracy investigator.; Nastase Abigail investigator.; Badami Abbas investigator.; Alvarez‐Garcia Jesus investigator.; Bowman‐Anger Lyndsey investigator.; Julien Lovelyn investigator.; Ortiz‐Bautista Carlos investigator.; Friedman‐Morocco Rachel investigator.; Gajurel Kiran investigator.; Cahuayme‐Zuniga Lizbeth investigator.; Wakefield Mark investigator.; Fung Monica investigator.; Theodoropoulos Nicole investigator.; Chuang Sally T. investigator.; Bhandaram Srividya investigator.; Veroux Massimiliano investigator.; Chopra Bhavna investigator.; Florescu Diana investigator.; Witteck Danielle investigator.; Diaz Daniela investigator.; Ripley Kathryn investigator.; Saharia Kapil investigator.; Akkina Sanjeev investigator.; McCarty Todd P. investigator.; Webb Ally investigator.; Arya Akanksha investigator.; Vedula Giridhar investigator.; El‐Amm Jose‐Marie investigator.; Katherine Dokus M. investigator.; Narayanan Arun investigator.; Cilene Leon Bueno de Camargo Priscila investigator.; Ouseph Rosemary investigator.; Breuckner Andrew investigator.; Luk Alfred investigator.; Aujayeb Avinash investigator.; Ganger Daniel investigator.; Keith Douglas S. investigator.; Meloni Federica investigator.; Haidar Ghady investigator.; Zapernick Lori investigator.; Moraels Megan investigator.; Goyal Nitender investigator.; Sharma Tanvi investigator.; Malhotra Uma investigator.; Kuo Alexander investigator.; Rossi Ana P. investigator.; Edwards Angelina investigator.; Keller Brian investigator.; Beneri Christy investigator.; Derringer Darby investigator.; Dominguez Edward investigator.; Carlson Elise investigator.; Hashim Faris investigator.; Murad Haris investigator.; Wilkens Heinrike investigator.; Neumann Henry investigator.; Gani Imran investigator.; Kahwaji Joseph investigator.; Popoola Joyce investigator.; Michaels Marian investigator.; Jakharia Niyati investigator.; Puing Alfredo investigator.; Motallebzadeh Reza investigator.; Velagapudi Ravi investigator.; Kapoor Rajan investigator.; Allam Sridhar investigator.; Silveira Fernanda investigator.; Vora Surabhi investigator.; Kelly Ursala M. investigator.; Reddy Uttam investigator.; Dharnidharka Vikas investigator.; Wadei Hani investigator.; Zurabi Lominadze investigator.;
• Is Part Of: American journal of transplantation. Volume 22:Issue 1(2022)
• Page Start: 279
• Page End: 288
• Publication Date: 2021-10-07
• Subjects: clinical research/practice -- infection and infectious agents ‐ viral -- infectious disease -- organ transplantation in general -- quality of care/care delivery; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.16840
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : Mortality among patients hospitalized for COVID‐19 has declined over the course of the pandemic. Mortality trends specifically in solid organ transplant recipients (SOTR) are unknown. Using data from a multicenter registry of SOTR hospitalized for COVID‐19, we compared 28‐day mortality between early 2020 (March 1, 2020–June 19, 2020) and late 2020 (June 20, 2020–December 31, 2020). Multivariable logistic regression was used to assess comorbidity‐adjusted mortality. Time period of diagnosis was available for 1435/1616 (88.8%) SOTR and 971/1435 (67.7%) were hospitalized: 571/753 (75.8%) in early 2020 and 402/682 (58.9%) in late 2020 ( p < .001). Crude 28‐day mortality decreased between the early and late periods (112/571 [19.6%] vs. 55/402 [13.7%]) and remained lower in the late period even after adjusting for baseline comorbidities (aOR 0.67, 95% CI 0.46–0.98, p = .016). Between the early and late periods, the use of corticosteroids (≥6 mg dexamethasone/day) and remdesivir increased (62/571 [10.9%] vs. 243/402 [61.5%], p < .001 and 50/571 [8.8%] vs. 213/402 [52.2%], p < .001, respectively), and the use of hydroxychloroquine and IL‐6/IL‐6 receptor inhibitor decreased (329/571 [60.0%] vs. 4/492 [1.0%], p < .001 and 73/571 [12.8%] vs. 5/402 [1.2%], p < .001, respectively). Mortality among SOTR hospitalized for COVID‐19 declined between early and late 2020, consistent with trends reported in the general population. The mechanism(s) underlying improved survival require further study. Abstract : Data from the pre‐vaccine era show declining mortality among solid organ transplant recipients hospitalized for COVID‐19 over the course of the pandemic. Kalil comments on page 12 .