Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study. Issue 1 (13th May 2021)

• Record Type: Journal Article
• Authors: Poos, Jackie M.; Russell, Lucy L.; Peakman, Georgia; Bocchetta, Martina; Greaves, Caroline V.; Jiskoot, Lize C.; van der Ende, Emma L.; Seelaar, Harro; Papma, Janne M.; van den Berg, Esther; Pijnenburg, Yolande A.L.; Borroni, Barbara; Sanchez‐Valle, Raquel; Moreno, Fermin; Laforce, Robert; Graff, Caroline; Synofzik, Matthias; Galimberti, Daniela; Rowe, James B.; Masellis, Mario; Tartaglia, Carmela; Finger, Elizabeth; Vandenberghe, Rik; de Medonça, Alexandre; Tagliavini, Fabrizio; Butler, Chris R.; Santana, Isabel; Ber, Isabelle Le; Gerhard, Alex; Ducharme, Simon; Levin, Johannes; Danek, Adrian; Otto, Markus; Sorbi, Sandro; Pasquier, Florence; van Swieten, John C.; Rohrer, Jonathan D.;
• Other Names: Rossor Martin N. investigator.; Fox Nick C. investigator.; Warren Jason D. investigator.; Moore Katrina investigator.; Convery Rhian investigator.; Swift Imogen J. investigator.; Shafei Rachelle investigator.; Heller Carolin investigator.; Todd Emily investigator.; Bouzigues Arabella investigator.; Cash David investigator.; Woollacott Ione investigator.; Zetterberg Henrik investigator.; Nelson Annabel investigator.; Nicholas Jennifer investigator.; Guerreiro Rita investigator.; Bras Jose investigator.; Thomas David L. investigator.; Mead Simon investigator.; Meeter Lieke investigator.; Panman Jessica investigator.; van Minkelen Rick investigator.; Barandiaran Myriam investigator.; Indakoetxea Begoña investigator.; Gabilondo Alazne investigator.; Tainta Mikel investigator.; Gorostidi Ana investigator.; Zulaica Miren investigator.; Díez Alina investigator.; Villanua Jorge investigator.; Borrego‐Ecija Sergi investigator.; Jaume Olives investigator.; Lladó Albert investigator.; Balasa Mircea investigator.; Antonell Anna investigator.; Bargallo Nuria investigator.; Premi Enrico investigator.; Gazzina Stefano investigator.; Gasparotti Roberto investigator.; Archetti Silvana investigator.; Black Sandra investigator.; Mitchell Sara investigator.; Rogaeva Ekaterina investigator.; Freedman Morris investigator.; Keren Ron investigator.; Tang‐Wai David investigator.; Thonberg Hakan investigator.; Öijerstedt Linn investigator.; Andersson Christin investigator.; Jelic Vesna investigator.; Arighi Andrea investigator.; Fenoglio Chiara investigator.; Scarpini Elio investigator.; Fumagalli Giorgio investigator.; Cope Thomas investigator.; Timberlake Carolyn investigator.; Rittman Timothy investigator.; Shoesmith Christen investigator.; Bartha Robart investigator.; Rademakers Rosa investigator.; Wilke Carlo investigator.; Karnarth Hans‐Otto investigator.; Bender Benjamin investigator.; Bruffaerts Rose investigator.; Vandamme Philip investigator.; Vandenbulcke Mathieu investigator.; Ferreira Catarina B. investigator.; Miltenberger Gabriel investigator.; Maruta Carolina investigator.; Verdelho Ana investigator.; Afonso Sónia investigator.; Taipa Ricardo investigator.; Caroppo Paola investigator.; Di Fede Giuseppe investigator.; Giaccone Giorgio investigator.; Prioni Sara investigator.; Redaelli Veronica investigator.; Rossi Giacomina investigator.; Tiraboschi Pietro investigator.; Duro Diana investigator.; Almeida Maria Rosario investigator.; Castelo‐Branco Miguel investigator.; Leitão Maria João investigator.; Tabuas‐Pereira Miguel investigator.; Santiago Beatriz investigator.; Gauthier Serge investigator.; Rosa‐Neto Pedro investigator.; Veldsman Michele investigator.; Thompson Paul investigator.; Langheinrich Tobias investigator.; Prix Catharina investigator.; Hoegen Tobias investigator.; Wlasich Elisabeth investigator.; Loosli Sandra investigator.; Schonecker Sonja investigator.; Anderl‐Straub Sarah investigator.; Lombardi Jolina investigator.; Bargalló Nuria investigator.; Benussi Alberto investigator.; Cantoni Valentina investigator.; Bertoux Maxime investigator.; Bertrand Anne investigator.; Brice Alexis investigator.; Camuzat Agnès investigator.; Colliot Olivier investigator.; Sayah Sabrina investigator.; Funkiewiez Aurélie investigator.; Rinaldi Daisy investigator.; Lombardi Gemma investigator.; Nacmias Benedetta investigator.; Saracino Dario investigator.; Bessi Valentina investigator.; Ferrari Camilla investigator.; Cañada Marta investigator.; Deramecourt Vincent investigator.; Kuchcinski Gregory investigator.; Lebouvier Thibaud investigator.; Ourselin Sebastien investigator.; Polito Cristina investigator.; Rollin Adeline investigator.;
• Is Part Of: Alzheimer's & dementia. Volume 13:Issue 1(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-13
• Subjects: cognition -- episodic memory -- executive function -- frontal lobe -- frontotemporal dementia -- genetic disorders -- neuropsychology -- temporal lobe -- voxel‐based morphometry; Alzheimer's disease -- Periodicals; Alzheimer's disease -- Diagnosis -- Periodicals; Dementia -- Periodicals; Dementia -- Diagnosis -- Periodicals; 616.831
• DOI: 10.1002/dad2.12185
• Languages: English
• ISSNs: 2352-8729

Abstract

Abstract: Introduction: We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT). Methods: The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [ C9orf72 ], 163 progranulin [ GRN ], and 73 microtubule‐associated protein tau [ MAPT ]) and 290 controls. Group differences and correlations with other neuropsychological tests were examined. We performed voxel‐based morphometry to investigate the underlying neural substrates of the FCSRT. Results: All symptomatic mutation carrier groups and presymptomatic MAPT mutation carriers performed significantly worse on all FCSRT scores compared to controls. In the presymptomatic C9orf72 group, deficits were found on all scores except for the delayed total recall task, while no deficits were found in presymptomatic GRN mutation carriers. Performance on the FCSRT correlated with executive function, particularly in C9orf72 mutation carriers, but also with memory and naming tasks in the MAPT group. FCSRT performance also correlated with gray matter volumes of frontal, temporal, and subcortical regions in C9orf72 and GRN, but mainly temporal areas in MAPT mutation carriers. Discussion: The FCSRT detects presymptomatic deficits in C9orf72 ‐ and MAPT ‐associated FTD and provides important insight into the underlying cause of memory impairment in different forms of FTD.