Differential effects of antiepileptic drugs on human bone cells. Issue 11 (2nd April 2019)

• Record Type: Journal Article
• Authors: Rocha, Sara; Ferraz, Ricardo; Prudêncio, Cristina; Fernandes, Maria Helena; Costa‐Rodrigues, João
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 11(2019:Nov.)
• Page Start: 19691
• Page End: 19701
• Publication Date: 2019-04-02
• Subjects: antiepileptic drugs -- osteoblastogenesis -- osteoclastogenesis; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.28569
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Antiepileptic drugs (AED) have been associated to in vivo deleterious consequences in bone tissue. The present work aimed to characterize the cellular and molecular effects of five different AED on human osteoclastogenesis and osteblastogenesis. It was observed that the different drugs had the ability to differentially modulate both processes, in a way dependent on the identity and dose of the AED. Shortly, valproic acid stimulated either osteoclastogenesis and osteoblastogenesis, whereas carbamazepine, gabapentin, and lamotrigine revealed an opposite behavior; topiramate elicited a decrease of osteoclast development and an increase in osteoblast differentiation. This is the first report describing the direct effects of different AED on human primary bone cells, which is a very important issue, because these drugs are usually consumed in long‐term therapeutics, with acknowledged in vivo effects in bone tissue. Abstract : The effects of antiepileptic drugs (AED) on human osteoclastgenesis and osteoblastogenesis were assessed. AED directly modulated osteoclastogenesis and osteoblastogenesis. The effects were dependent on the identity and dose of the AED.