Long‐term trajectories and current BMI are associated with poorer cognitive functioning in middle‐aged adults at high Alzheimer's disease risk. Issue 1 (31st December 2021)

• Record Type: Journal Article
• Authors: West, Rebecca K.; Ravona‐Springer, Ramit; Sharvit‐Ginon, Inbal; Ganmore, Ithamar; Manzali, Sigalit; Tirosh, Amir; Golan, Sapir; Boccara, Ethel; Heymann, Anthony; Beeri, Michal Schnaider
• Is Part Of: Alzheimer's & dementia. Volume 13:Issue 1(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-31
• Subjects: adiposity -- Alzheimer's disease -- cognition -- cognitive decline -- obesity -- parental history of Alzheimer's disease -- risk factors; Alzheimer's disease -- Periodicals; Alzheimer's disease -- Diagnosis -- Periodicals; Dementia -- Periodicals; Dementia -- Diagnosis -- Periodicals; 616.831
• DOI: 10.1002/dad2.12247
• Languages: English
• ISSNs: 2352-8729

Abstract

Abstract: Introduction: We examined relationships of body mass index (BMI) with cognition in middle‐aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods: Participants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history. Analyses of covariance examined associations of long‐term trajectories of BMI with cognition. Results: Higher BMI was associated with worse language ( P = .045). Interactions of BMI with parental history were significant for episodic memory ( P = .023), language (p = .027), working memory ( P = .006), global cognition ( P = .008); associations were stronger among participants with maternal history. Interactions of BMI trajectories with parental history were significant for episodic memory ( P = .017), language ( P = .013), working memory ( P = .001), global cognition ( P = .005), with stronger associations for maternal history. Discussion: Higher BMI and overweight/obese trajectories were associated with poorer cognition in adults with maternal history of AD, but not those with paternal history.