Overexpression of GAS5 inhibits abnormal activation of Wnt/β‐catenin signaling pathway in myocardial tissues of rats with coronary artery disease. Issue 7 (3rd December 2018)

• Record Type: Journal Article
• Authors: Li, Xuexiang; Hou, Linlin; Cheng, Ziping; Zhou, Shu; Qi, Jinwei; Cheng, Jinglin
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 7(2019:Jul.)
• Page Start: 11348
• Page End: 11359
• Publication Date: 2018-12-03
• Subjects: coronary heart disease -- diagnostic efficacy -- inflammatory injury -- long noncoding RNAs growth arrest‐specific transcript 5 (LncRNA GAS5) -- myocardial injury -- oxidative stress -- Wnt/β‐catenin signaling pathway; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.27792
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Objective: The aim of this study is to investigate the clinical value of long noncoding RNA growth arrest‐specific transcript 5 (LncRNA GAS5) in the diagnosis of coronary artery disease (CAD) and its protective effect on myocardial injury in rats with CAD. Methods: Patients with CAD and healthy controls were selected to measure the expression of GAS5, and further to perform the correlation analysis and ROC curve. In addition, the rat models of CAD were also established to observe the effect of GAS5 on hyperlipidemia, myocardial injury, cardiomyocyte apoptosis, oxidative stress, and inflammatory injury of rats with CAD, and the effect of the Wnt/β‐catenin signaling pathway was also determined. Results: Overexpression of GAS5 in CAD rats determines improvement of hyperlipidemia, attenuation of myocardial injury, inhibition of cardiomyocyte apoptosis, oxidative stress, inflammatory injury, and abnormal activation of the Wnt/β‐catenin signaling pathway in myocardial tissues. Conclusion: Our study demonstrates that downregulation of GAS5 is found in CAD, and overexpression of GAS5 inhibits abnormal activation of the Wnt/β‐catenin signaling pathway in myocardial tissues of CAD rats.