Metabolic syndrome, Mediterranean diet, and polyphenols: Evidence and perspectives. Issue 5 (14th October 2018)

• Record Type: Journal Article
• Authors: Finicelli, Mauro; Squillaro, Tiziana; Di Cristo, Francesca; Di Salle, Anna; Melone, Mariarosa Anna Beatrice; Galderisi, Umberto; Peluso, Gianfranco
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 5(2019:May)
• Page Start: 5807
• Page End: 5826
• Publication Date: 2018-10-14
• Subjects: Mediterranean diet -- metabolic syndrome -- olive oil -- polyphenols -- resveratrol; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.27506
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Metabolic syndrome (MetS) is defined as the co‐occurrence of metabolic risk factors that includes insulin resistance, hyperinsulinemia, impaired glucose tolerance, type 2 diabetes mellitus, dyslipidemia, and visceral obesity. The clinical significance of MetS consists of identifying a subgroup of patients sharing a common physiopathological state predisposing to chronic diseases. Clinical and scientific studies pinpoint lifestyle modification as an effective strategy aiming to reduce several features accountable for the risk of MetS onset. Among the healthy dietary patterns, the Mediterranean diet (MedDiet) emerges in terms of beneficial properties associated with longevity. Current evidence highlights the protective effect exerted by MedDiet on the different components of MetS. Interestingly, the effect exerted by polyphenols contained within the representative MedDiet components (i.e., olive oil, red wine, and nuts) seems to be accountable for the beneficial properties associated to this dietary pattern. In this review, we aim to summarize the principal evidence regarding the effectiveness of MedDiet–polyphenols in preventing or delaying the physiopathological components accountable for MetS onset. These findings may provide useful insights concerning the health properties of MedDiet–polyphenols as well as the novel targets destined to a tailored approach to MetS. Abstract : The Mediterranean diet (MedDiet) exerts a protective effect on the different components of metabolic syndrome. Interestingly, the polyphenols contained within the representative components of MedDiet seems to be responsible for the beneficial properties associated to this dietary pattern.