NcRNAs associated with drug resistance and the therapy of digestive system neoplasms. Issue 11 (2nd April 2019)

• Record Type: Journal Article
• Authors: Feng, Wei; Su, Zhangyao; Yin, Qingqing; Zong, Wei; Shen, Xianjuan; Ju, Shaoqing
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 11(2019:Nov.)
• Page Start: 19143
• Page End: 19157
• Publication Date: 2019-04-02
• Subjects: digestive system cancer -- drug resistance -- exosomes -- lncRNA -- miRNA -- therapy; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.28551
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Digestive system cancer remains a common cancer and the main cause of cancer‐related death worldwide. Drug resistance is a major challenge in the therapy of digestive system cancer, and represents a primary obstacle in the treatment of cancer by restricting the efficiency of both traditional chemotherapy and biological therapies. Existing studies indicate that noncoding RNAs play an important role in the evolution and progression of drug resistance in digestive system cancer, mainly by modulating drug transporter‐related proteins, DNA damage repair, cell‐cycle‐related proteins, cell apoptosis‐related proteins, drug target‐related proteins, and the tumor microenvironment. In this review, we address the potential mechanisms of ncRNAs underlying drug resistance in digestive system tumors and discuss the possible application of ncRNAs against drug resistance in digestive system tumors. Abstract : Our manuscript summarizes the research on the resistance of noncoding RNA (ncRNA) to tumors in the digestive system, discusses the application prospects of ncRNA in tumor treatment, and hopes to make contributions to clinical applications in the future.