18F‐FET PET maximum standard uptake value and WHO tumour classification grade in glioma. Issue 3 (12th September 2021)

• Record Type: Journal Article
• Authors: Tatkovic, Annaleis; McBean, Rhiannon; Perkins, Ebony; Wong, David
• Is Part Of: Journal of medical imaging and radiation oncology. Volume 66:Issue 3(2022)
• Page Start: 332
• Page End: 336
• Publication Date: 2021-09-12
• Subjects: 18F‐FET -- brain tumour -- glioma staging -- MRI -- neuro‐oncology imaging -- PET; Radiology, Medical -- Periodicals; Radiology, Medical -- Australasia -- Periodicals; 616.0757
• DOI: 10.1111/1754-9485.13322
• Languages: English
• ISSNs: 1754-9477

Abstract

Abstract: Background: In the area of oncology, molecular imaging techniques are becoming increasingly utilised. In neuro‐oncology imaging, 18 Fluoro‐O‐(2) fluoroethyl‐L‐tyrosine ( 18 F‐FET) is one of the molecular tracers used in positron‐emission tomography (PET). Here, we investigated the correlation between maximum standard uptake value (SUV) of 18 F‐FET PET and histologically determined World Health Organization (WHO) grade in glioma. Patients and Methods: This was a retrospective review of all 18 F‐FET PET studies conducted between August 2014 and August 2019. Review was conducted to identify imaging studies performed on patients who had a glioma with histopathology results from surgical resection or biopsy available. Results: A total of 31 18 F‐FET PET studies of histologically confirmed glioma were included. WHO grades ranged from II‐IV. A positive correlation between maximum SUV uptake on 18 F‐FET PET and WHO grade was observed. Conclusions: There was a correlation identified between WHO glioma grade and maximum SUV on 18 F‐FET PET. Further studies are recommended to explore this relationship.