The role of cell adhesion in hematopoiesis and leukemogenesis. Issue 11 (13th April 2019)

• Record Type: Journal Article
• Authors: Heath, Jessica L.; Cohn, Gabriel M.; Zaidi, Sayyed K.; Stein, Gary S.
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 11(2019:Nov.)
• Page Start: 19189
• Page End: 19198
• Publication Date: 2019-04-13
• Subjects: bone marrow -- cell adhesion -- chemotherapy resistance -- leukemia -- microenvironment; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.28636
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: The cells of the bone marrow microenvironment are emerging as important contributors and regulators of normal hematopoiesis. This microenvironment is perturbed during leukemogenesis, and evidence points toward a bidirectional communication between leukemia cells and the normal cells of the bone marrow, mediated by direct cell–cell contact as well as soluble factors. These interactions are increasingly appreciated to play a role in leukemogenesis and possibly in resistance to chemotherapy. In fact, several compounds that specifically target the bone marrow microenvironment, including inhibitors of cell adhesion, are being tested as adjuncts to leukemia therapy. Abstract : The cells of the bone marrow microenvironment are emerging as important contributors and regulators of normal and malignant hematopoiesis. Evidence points toward a bidirectional communication between leukemia cells and the normal cells of the bone marrow, mediated by direct cell–cell contact as well as soluble factors, which may play a role in leukemogenesis and resistance to chemotherapy. Ongoing studies in this field will expand our understanding of the detailed molecular mechanisms underlying these interactions, ultimately allowing for the development of therapies directed at the microenvironment itself.