The role of ErbB3 binding protein 1 in cancer: Friend or foe?. Issue 12 (4th August 2018)

• Record Type: Journal Article
• Authors: Nguyen, Dang Quan; Hoang, Dinh Hoa; Nguyen Vo, Thanh Thao; Huynh, Vu; Ghoda, Lucy; Marcucci, Guido; Nguyen, Le Xuan Truong
• Is Part Of: Journal of cellular physiology. Volume 233:Issue 12(2018:Dec.)
• Page Start: 9110
• Page End: 9120
• Publication Date: 2018-08-04
• Subjects: cancer -- Ebp1 -- ErbB3; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.26951
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract : ErbB3, a member of the epidermal growth factor receptor family, reportedly plays an essential role in the regulation of cancer progression and therapeutic resistance. Numerous studies have indicated that ErbB3 binding protein 1 (Ebp1), a binding partner for ErbB3, plays an important regulatory role in the expression and function of ErbB3, but there is no agreement as to whether Ebp1 also has an ErbB3‐independent function in cancer and how it might contribute to tumorigenesis. In this review, we will discuss the different functions of the two Ebp1 isoforms, p48 and p42, that may be responsible for the potentially dual role of Ebp1 in cancer growth. Abstract : Numerous studies have indicated that ErbB3 binding protein 1 (Ebp1), a binding partner for ErbB3, plays an important regulatory role in the expression and function of ErbB3, but there is no agreement as to whether Ebp1 also has an ErbB3‐independent function in cancer and how it might contribute to tumorigenesis. In this review, we will discuss the different functions of the two Ebp1 isoforms, p48 and p42, that may be responsible for the potentially dual role of Ebp1 in cancer growth.