Comprehensive phenotyping of human peripheral blood B lymphocytes in healthy conditions. Issue 2 (18th October 2021)

• Record Type: Journal Article
• Authors: Carsetti, Rita; Terreri, Sara; Conti, Maria Giulia; Fernandez Salinas, Ane; Corrente, Francesco; Capponi, Claudia; Albano, Christian; Piano Mortari, Eva
• Is Part Of: Cytometry. Volume 101:Issue 2(2022)
• Page Start: 131
• Page End: 139
• Publication Date: 2021-10-18
• Subjects: B cell subsets -- flow cytometry -- human B cells -- phenotyping; Flow cytometry -- Periodicals; Imaging systems in biology -- Periodicals; Imaging systems in medicine -- Periodicals; Diagnostic imaging -- Periodicals; 571.605
• DOI: 10.1002/cyto.a.24507
• Languages: English
• ISSNs: 1552-4922

Abstract

Abstract: The B cell compartment provides innate and adaptive immune defenses against pathogens. Different B cell subsets, reflecting the maturation stages of B cells, have noninterchangeable functions and roles in innate and adaptive immune responses. In this review, we provide an overview of the B cell subsets present in peripheral blood of healthy individuals. A specific gating strategy is also described to clearly and univocally identify B cell subsets based on the their phenotypic traits by flow cytometric analysis.