Hepatoprotective effect of Aloe vera against cartap‐ and malathion‐induced toxicity in Wistar rats. Issue 10 (19th March 2019)

• Record Type: Journal Article
• Authors: Gupta, Vivek K.; Siddiqi, Nikhat J.; Ojha, Anil K.; Sharma, Bechan
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 10(2019:Oct.)
• Page Start: 18329
• Page End: 18343
• Publication Date: 2019-03-19
• Subjects: antioxidants -- malathion -- oxidative stress -- pesticide -- phytochemicals -- thiocarbamate; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.28466
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Exposure to mixture of pesticides in agricultural practices pose a serious threat to the nontarget animals. In present work, we have evaluated the synergistic effect of cartap and malathion on rat liver followed by impact of Aloe vera leaves aqueous extract, which is not known. The animals in eight groups were used; each containing six rats: Group 1 acted as a control, Group 2—control with A. vera leaves aqueous extract, Group 3—with cartap, Group 4—with malathion, Group 5—with mixture of cartap and malathion, Group 6—cartap with the pretreatment of A. vera leaf extract, Group 7—malathion with the pretreatment of A. vera leaf extract, Group 8—mixture of cartap and malathion with the pretreatment of A. vera leaf extract . The animals treated for 15 days were killed after 24hr of last treatment. The biochemical studies in the rat liver demonstrated significant perturbations in the levels of nonenzymatic (glutathione and malondialdehyde) and enzymatic (superoxide dismutase, catalase, and glutathione‐ S ‐transferase) antioxidative indices. The histopathological examination of liver revealed serious congestion in central vein and the disorganization of hepatic cords due to pesticide treatment. The administration of A. vera leaves aqueous extract was able to markedly protect rat liver from the pesticides‐induced toxicity. The data indicated that pesticides were able to significantly induce oxidative stress which was substantially reduced by the application of plant extract . Abstract : The pretreatment of aqueous extract of Aloe vera leaf in rats proved to act as a potential antioxidant which could be implicated toward protection of the integrity of liver of rat against pesticide intoxication. The results from present study may be utilized for developing appropriate pesticides formulation for optimum crop benefit with minimum risk to the environmental health including that of humans and animals. The antioxidant potential of A. vera may be exploited as a cost‐effective therapeutic supplement so as to reduce drug‐induced oxidative stress‐mediated toxicity.