Stem cell therapy: A novel approach for myocardial infarction. Issue 10 (27th February 2019)

• Record Type: Journal Article
• Authors: Parizadeh, Seyed Mostafa; Jafarzadeh‐Esfehani, Reza; Ghandehari, Maryam; Parizadeh, Mohammad Reza; Ferns, Gordon A.; Avan, Amir; Hassanian, Seyed Mahdi
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 10(2019:Oct.)
• Page Start: 16904
• Page End: 16912
• Publication Date: 2019-02-27
• Subjects: cardiac stem cells -- myocardial infraction -- stem cell therapy; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.28381
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide. Until recently, it was thought that myocardium was not able to repair itself, but studies have now shown that resident cardiac stem cells have regenerative capacity, and stem cell therapy may be a novel approach for cardiac muscle repair and regeneration. Stem cell‐derived paracrine factors have been shown to regulate ventricular remodeling, inflammation, apoptosis, cardiomyocytes regeneration, and neovascularization in regions of infarcted cardiac tissue. In this review, we summarize the evidence from cellular, animal, and clinical studies supporting the potential clinical significance of stem cell therapy as a novel therapeutic approach for the treatment of MI. Abstract : In this review, we summarize the evidence from cellular, animal, and clinical studies supporting the potential clinical significance of stem cell therapy as a novel therapeutic approach for the treatment of myocardial infraction (MI).