The potential utility of melatonin in the treatment of childhood cancer. Issue 11 (3rd April 2019)

• Record Type: Journal Article
• Authors: Chao, Yu‐Hua; Wu, Kang‐Hsi; Yeh, Chia‐Ming; Su, Shih‐Chi; Reiter, Russel J.; Yang, Shun‐Fa
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 11(2019:Nov.)
• Page Start: 19158
• Page End: 19166
• Publication Date: 2019-04-03
• Subjects: antioxidant -- childhood cancer -- melatonin -- therapeutic agent; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.28566
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Childhood cancer management has improved considerably, with the overall objective of preventing early‐life cancers completely. However, cancer remains a major cause of death in children, with the survivors developing anticancer treatment‐specific health problems. Therefore, the anticancer treatment needs further improvement. Melatonin is a effective antioxidant and circadian pacemaker. Through multiple mechanisms, melatonin has significant positive effects on multitude adult cancers by increasing survival and treatment response rates, and slowing disease progression. In addition, melatonin appears to be safe for children. As an appealing therapeutic agent, we herein address several key concerns regarding melatonin's potential for treating children with cancer. Abstract : Melatonin has significant positive effects on multitude adult cancers by increasing survival and treatment response rates, and slowing disease progression.