Schwann cell precursors generate sympathoadrenal system during zebrafish development. Issue 10 (28th June 2021)

• Record Type: Journal Article
• Authors: Kamenev, Dmitrii; Sunadome, Kazunori; Shirokov, Maxim; Chagin, Andrey S.; Singh, Ajeet; Irion, Uwe; Adameyko, Igor; Fried, Kaj; Dyachuk, Vyacheslav
• Other Names: Johnson Elizabeth guestEditor.; Jones Kevin guestEditor.
• Is Part Of: Journal of neuroscience research. Volume 99:Issue 10(2021)
• Page Start: 2540
• Page End: 2557
• Publication Date: 2021-06-28
• Subjects: axons -- chromaffin cells -- GTX128374 -- motor neurons -- neurogenesis -- RRID:AB_162542 -- RRID:AB_303395 -- RRID:AB_2313713 -- RRID:AB_2716636 -- RRID:AB_2762830 -- RRID:AB_2762834 -- RRID:AB_2861427 -- RRID:AB_2887225 -- RRID:AB_10615776 -- RRID:SCR_003070 -- RRID:SCR_002798 -- RRID:SCR_007370 -- RRID:SCR_018163 -- sympathetic neurons -- teleost fish; Neurobiology -- Periodicals; 612
• DOI: 10.1002/jnr.24909
• Languages: English
• ISSNs: 0360-4012

Abstract

Abstract: The autonomic portion of the peripheral nervous system orchestrates tissue homeostasis through direct innervation of internal organs, and via release of adrenalin and noradrenalin into the blood flow. The developmental mechanisms behind the formation of autonomic neurons and chromaffin cells are not fully understood. Using genetic tracing, we discovered that a significant proportion of sympathetic neurons in zebrafish originates from Schwann cell precursors (SCPs) during a defined period of embryonic development. Moreover, SCPs give rise to the main portion of the chromaffin cells, as well as to a significant proportion of enteric and other autonomic neurons associated with internal organs. The conversion of SCPs into neuronal and chromaffin cells is ErbB receptor dependent, as the pharmacological inhibition of the ErbB pathway effectively perturbed this transition. Finally, using genetic ablations, we revealed that SCPs producing neurons and chromaffin cells migrate along spinal motor axons to reach appropriate target locations. This study reveals the evolutionary conservation of SCP‐to‐neuron and SCP‐to‐chromaffin cell transitions over significant growth periods in fish and highlights relevant cellular‐genetic mechanisms. Based on this, we anticipate that multipotent SCPs might be present in postnatal vertebrate tissues, retaining the capacity to regenerate autonomic neurons and chromaffin cells. Abstract : The illustration of the generation of sympathetic neurons and chromaffin cells from SCPs associated with nerves during zebrafish development. In fish, peripheral nerve‐associated SCPs detach and generate the majority of sympathetic neurons and chromaffin cells over significant periods of development and growth.