Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home): feasibility of a home-based double-blind randomised controlled trial to improve gait and cognition in individuals at risk for dementia. Issue 3 (31st March 2022)

• Record Type: Journal Article
• Authors: McGibbon, Chris; Jarrett, Pam; Handrigan, Grant; Bouchard, Danielle; Tranchant, Carole C C; Sexton, Andrew M; Yetman, Linda; Robinson, Bryn; Crapoulet, Stephanie; Chamard-Witkowski, Ludivine; Liu-Ambrose, Teresa; Middleton, Laura Elizabeth; Almeida, Quincy J; Bherer, Louis; Lim, Andrew; Speechley, Mark; Kamkar, Nellie; Montero Odasso, Manuel
• Other Names: author non-byline.; Chertkow Howard author non-byline.; Belleville Sylvie author non-byline.; Feldman Howard author non-byline.; Montero-Odasso Manuel author non-byline.; Nygaard Haakon author non-byline.; Alcock Danielle author non-byline.; Anderson Nicole author non-byline.; Banks Sarah author non-byline.; Brewster Paul author non-byline.; Chan Senny author non-byline.; Cuesta Marc author non-byline.; Das Samir author non-byline.; Evans Carol author non-byline.; Ferland Guylaine author non-byline.; Herold Tati author non-byline.; Hofer Scott author non-byline.; Itzhak Inbal author non-byline.; Jacobs Diane author non-byline.; Jarrett Pam author non-byline.; Kamkar Nellie author non-byline.; Lim Andrew author non-byline.; Lupo Jody-Lynn author non-byline.; Madlensky Lisa author non-byline.; McGibbon Chris author non-byline.; Messer Karen author non-byline.; Mohades Zia author non-byline.; Revta Carolyn author non-byline.; Robillard Julie author non-byline.; Slack Penny author non-byline.; Smith Eric author non-byline.; Speechley Mark author non-byline.; Walker Jennifer author non-byline.; Zou Jingjing author non-byline.;
• Is Part Of: BMJ open. Volume 12:Issue 3(2022)
• Publication Date: 2022-03-31
• Subjects: Dementia -- Physiology -- GERIATRIC MEDICINE -- Neuropathology; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2021-059988
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: Physical exercise and cognitive training have the potential to enhance cognitive function and mobility in older adults at risk of Alzheimer's disease and related dementia (ADRD), but little is known about the feasibility of delivering multidomain interventions in home settings of older adults at risk of ADRD. This study aims to assess the feasibility of home-based delivery of exercise and cognitive interventions, and to evaluate the relationship between participants' intervention preferences and their subsequent adherence. Secondary objectives include the effect of the interventions on ADRD risk factors, including frailty, mobility, sleep, diet and psychological health. Methods and analysis: The SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home) feasibility trial is a randomised control trial that follows a 2×2 factorial design, with a 16-week home-based intervention programme (3 sessions per week) of physical exercises and cognitive training. Participants will be randomised in blocks of four to one of the following four arms: (1) combined exercise (aerobic and resistance)+cognitive training (NEUROPEAK); (2) combined exercise+control cognitive training (web searching); (3) control exercise (balance and toning)+cognitive training; and (4) control exercise+control cognitive training. SYNERGIC@Home will be implemented through video conferencing. Baseline and post-intervention assessments at 4-month and 10-month follow-up will include measures of cognition, frailty, mobility, sleep, diet and psychological health. Primary feasibility outcome is adherence to the interventions. Primary analytic outcome is the relationship between pre-allocation preference for a given intervention and subsequent adherence to the allocated intervention. A series of secondary analytic outcomes examining the potential effect of the individual and combined interventions on cognitive, mobility and general well-being will be measured at baseline and follow-up. Ethics and dissemination: Ethics approval was granted by the relevant research ethics boards. Findings of the study will be presented to stakeholders and published in peer-reviewed journals and at provincial, national and international conferences. Trial registration number: NCT04997681, Pre-results.