Clinically Meaningful Change in Sexual Desire in the Psychosexual Daily Questionnaire in Older Men from the TTrials. Issue 7 (14th May 2019)

• Record Type: Journal Article
• Authors: Stephens-Shields, Alisa J.; Wang, Christina; Preston, Peter; Snyder, Peter J.; Swerdloff, Ronald S.
• Is Part Of: Journal of sexual medicine. Volume 16:Issue 7(2019)
• Page Start: 951
• Page End: 953
• Publication Date: 2019-05-14
• Subjects: Clinically Meaningful Change -- Sexual Desire -- Sexual Function Assessment -- Testosterone Treatment; Sexual disorders -- Periodicals; Sex -- Periodicals; Sexual health -- Periodicals; 616.69005
• DOI: 10.1016/j.jsxm.2019.04.003
• Languages: English
• ISSNs: 1743-6095

Abstract

Abstract: Background: A recent study of older men participating in the Testosterone Trials (TTrials) defined a clinically meaningful change in the Psychosexual Daily Questionnaire (PDQ) question 4 in hypogonadal men age ≥65 years. This study defines clinically meaningful change in the same population for sexual desire assessed by PDQ question 1. Aim: To determine a clinically meaningful change in the answers to question 1 of the PDQ in hypogonadal older men. Methods: Participants in the Sexual Function Trial of the TTrials were randomly divided into a training and test set. Anchor-based methods, including regression analysis, receiver operating characteristic curves, and empirical cumulative distribution functions, were used to determine a clinically meaningful change on question 1 in the training set, and the selected threshold was evaluated in the test set for an effect of testosterone treatment. Results: A clinically meaningful increase in question 1 of the PDQ was determined to be ≥0.7 points. Clinical Implications: Question 1 of the PDQ can be used to assess sexual desire in response to testosterone treatment. Strengths & Limitations: Data were obtained from a single large study of older hypogonadal men. Conclusion: Clinically meaningful improvement of sexual desire is a change of ≥0.7 in the score of question 1 of the PDQ.