Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder. (1st April 2023)

• Record Type: Journal Article
• Authors: Hernández-Rubio, Anna; Sanvisens, Arantza; Barbier-Torres, Lucía; Blanes, Rafael; Miquel, Laia; Torrens, Marta; Rubio, Gabriel; Bolao, Ferran; Zuluaga, Paola; Fuster, Daniel; Rodríguez de Fonseca, Fernando; Farré, Magí; Muga, Robert; Study, CohRTA; Center, Coordinating; Sanvisens, Arantza; Zuluaga, Paola; Fuster, Daniel; Hernández-Rubio, Anna; Farré, Magí; Papasseit, Esther; Pérez-Mañá, Clara; Poyatos, Lourdes; García-Marchena, Nuria; Abellí, Enric; Muga, Robert; Short, Antonio; Moranta, Catalina; Blanes, Rafael; Rubio, Gabriel; Sion, Ana; Miquel, Laia; Ortega, Lluisa; Bruguera, Pol; Caballeria, Elsa; Messeguer, Ana; Torrens, Marta; Fonseca, Francina; Ignacio Mestre-Pinto, Juan; Alías, María; Dinamarca, Fernando; Bolao, Ferran; Rodríguez de Fonseca, Fernando; Javier Pavón-Morón, Francisco; Araos, Pedro; Flores-López, María; Serrano, Antonia; Marcos, Miguel; Martín, Candelaria; Pérez-Hernández, Onán; Manzanares, Jorge; Illescas, Lucía;
• Is Part Of: Drug and alcohol dependence. Volume 245(2023)
• Publication Date: 2023-04-01
• Subjects: ALF advanced liver fibrosis -- ALT alanine aminotransferase -- AST aspartate aminotransferase -- AUD alcohol use disorder -- CI confidence interval -- eGFR estimted glomerular filtration rate -- ESR erythrocyte sedimentation rate -- FIB4 fibrosis-4 index -- GGT gamma glutamyl transpeptidase -- HUGTP Hospital Universitari Germans Trias i Pujol -- hypoCa hypocalcemia -- hypoK hypokalemia -- hypoMg hypomagnesemia -- hypoNa hyponatremia -- IQR interquartile range -- Mg magnesium -- OR odds ratio -- SDU standard drink units; Alcohol use disorder -- Magnesium deficiency -- Oxidative stress -- Electrolyte disturbances; Drug abuse -- Periodicals; Alcoholism -- Periodicals; 616.86
• DOI: 10.1016/j.drugalcdep.2023.109822
• Languages: English
• ISSNs: 0376-8716

Abstract

Abstract: Introduction: Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD. Patients and Methods: Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission. Results: 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41–56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3–23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0–26.2) were the only factors associated with hypoMg. Conclusions: Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg. Highlights: Serum hypomagnesemia is the most common electrolyte disturbance in patients with AUD. Liver damage and glomerular dysfunction were associated with hypomagnesemia in patients with AUD. Hypomagnesemia is several times more likely to occur among AUD patients with hyponatremia or hypokalemia.