Two new dicyclic C-geranylflavanones isolated from Paulownia fortunei and their cytotoxicity. (April 2023)

• Record Type: Journal Article
• Authors: Liu, Wei-guo; Xiao, Cheng-mei; Li, Jun; Wu, Su-ying; Zhang, Wen-chao; Kong, Ling-tao; Tang, Wen-Zhao; Jia, Xian-hui
• Is Part Of: Phytochemistry letters. Volume 54(2023)
• Page Start: 97
• Page End: 100
• Publication Date: 2023-04
• Subjects: Paulownia fortunei (Seem.) Hemsl -- Dicyclic C-geranylflavanones -- Fortunones D and E -- Cytotoxicity -- Human lung cancer cell A549; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2023.02.001
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: Two novel dicyclic C -geranylated flavanones, fortunones D (1 ) and E (2 ), were isolated from the fresh mature fruits of Paulownia fortunei (Seem.) Hemsl. Their structures were elucidated by the extensive spectroscopic data analyses (UV, HRMS NMR, and CD). Each of these two isolated compounds possessed an unusual dicyclic geranyl group. Compounds 1 was more sensitive to human lung cancer cell A549 and exhibited potential anti-tumor effect (IC50 = 9.72 μ M). Graphical Abstract: ga1 Highlights: Two new dicyclic C -geranylflavanones were isolated from P. fortunei fruits. Their geranyl modifications were unusual for naturally occurred C -geranylated flavonoids. Fortunone D displayed potential cytotoxic effect on human lung cancer cell A549.