Cycloartane triterpene glycosides from Actaea vaginata. (April 2023)

• Record Type: Journal Article
• Authors: Zhang, Min-Li; Li, Yi-Min; Zhao, Zi-Xuan; Li, Xiang-Yuan; Sun, Zhao-Cui; Ma, Guo-Xu; Yang, Mei-Hua; Xu, Xu-Dong; Zhang, Xiao-Feng; Wu, Hai-Feng; Zou, Qiong-Yu; Giloi, Nelbon
• Is Part Of: Phytochemistry letters. Volume 54(2023)
• Page Start: 114
• Page End: 118
• Publication Date: 2023-04
• Subjects: Actaea vaginata -- Cycloartane triterpene glycoside -- Cytotoxicity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2023.02.006
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: Phytochemical investigation of the whole plant of Actaea vaginata led to the isolation of five cycloartane triterpene glycosides, including three new Actaeoside A−C (1 −3 ) along with two known analogues, beesiosides E (4 ) and N (5 ). Their structures were elucidated by NMR, HRESIMS and chemical analysis. The cytotoxicity of compounds (1 −5 ) was assayed against HT-29 and HepG2 cancer cell lines. All the isolates showed moderate degrees of inhibitory activity against the HT-29 with IC50 values in a range of 18.2–27.8 μM. Graphical Abstract: ga1 Highlights: Five cycloartane triterpenoid glycosides were isolated from Actaea vaginata. Three new and two known compounds were identified by spectroscopic analyses and chemical methods. Cytotoxicity against HepG2 and HT-29 cancer cell lines were evaluated.