New triterpenoids and a dibenzocyclooctadiene lignan from the leaves of Schisandra chinensis. (April 2023)

• Record Type: Journal Article
• Authors: Zhang, Yi-Qiang; Liu, Yan; Wen, Bo; Wang, Si-Yi; Jiang, Peng; Wu, Jia-Tong; Pan, Juan; Guan, Wei; Kuang, Hai-Xue; Yang, Bing-You
• Is Part Of: Phytochemistry letters. Volume 54(2023)
• Page Start: 57
• Page End: 62
• Publication Date: 2023-04
• Subjects: Schisandra chinensis -- Schinortriterpenoids -- Dibenzocyclooctadiene lignans -- Cytotoxicity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2023.01.020
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: Five schinortriterpenoids and seven lignans, were isolated from the leaves of Schisandra chinensis, including one undescribed schinortriterpenoid, schinensilactone C (1 ), one new lignan, schinlignan H (3 ), together with 20- epi -schilancitrilactone A (2 ) obtained as a natural product. Their structures were established by analysis of their spectroscopic data including MS, IR, 1D- and 2D NMR spectra. The absolute configuration of 1 was confirmed by single-crystal X-ray diffraction and that of the biphenyl ring in 3 was assigned by CD spectroscopy. Compounds 6, 9 and 11 are reported from Schisandra for the first time. All compounds were evaluated for their cytotoxic activity against LN299 cell line, (with doxorubicin as the positive control, IC50 = 0.49 μ M), and compound 4 exhibited significant activity with an IC50 value of 0.36 μ M. Graphical Abstract: ga1 Highlights: Two undescribed compounds and a new natural product were obtained from the leaves of Schisandra chinensis . The three compounds are schinortriterpenoids and dibenzocyclooctadiene lignan. The absolute configuration of 1 was confirmed by single-crystal X-ray diffraction. Compound 4 exhibited significant cytotoxic activity with IC50 value of 0.36 μ M.