Chemical constituents from the fungus Phellinus baumii and their anti-inflammatory activity. (April 2023)

• Record Type: Journal Article
• Authors: Zhao, Yu-Qing; Dong, Xin-Yue; Ning, Jin-Lei; Jin, Ying-Xue; Wang, Guo-Kai; Feng, Tao
• Is Part Of: Phytochemistry letters. Volume 54(2023)
• Page Start: 18
• Page End: 22
• Publication Date: 2023-04
• Subjects: Phellinus baumii -- Sesquiterpenes -- Alkyl-benzene derivatives -- Anti-inflammatory activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2022.12.017
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: Chemical investigation on the fungus Phellinus baumii led to the isolation of twenty-two compounds including two undescribed sesquiterpenes, namely phellinbaumins A and B, and three undescribed alkyl-benzene derivatives, namely phellinbaumins C–E. Phellinbaumins A and D displayed moderate inhibitory activities on nitric oxide (NO) production with IC50 values of 31.7 and 24.3 μ M, respectively. Graphical Abstract: ga1 Highlights: Twenty-two compounds have been isolated from Phellinus baumii . Five undescribed metabolites have been identified. The structures were established by means of spectroscopic methods. Two compounds exhibited inhibitory activity on NO production.