Cardiac sapogenins from Periploca forrestii. (April 2023)

• Record Type: Journal Article
• Authors: Jin, Jun; Meng, Man; Jian, Jun-you; Gu, Wei; Yuan, Chun-mao; Hao, Xiao-jiang; Huang, Lie-jun
• Is Part Of: Phytochemistry letters. Volume 54(2023)
• Page Start: 70
• Page End: 75
• Publication Date: 2023-04
• Subjects: Apocynaceae -- Periploca forrestii -- Cardiac sapogenins -- MG-63; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2023.01.009
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: Four new cardiac sapogenins, named periplogenins D-G (1–4 ), one new natural product, 3 β -hydroxycard-5, 14, 20(22)-trienolide (5 ), along with three known compounds, periforgenin A (6 ), periplogenin (7 ) and 3 β, 5 β -dihydroxycard-14, 20(22)-dienolide (8 ) were isolated from the stems and roots of Periploca forrestii . Their structures were confirmed by NMR spectroscopic analyses, ESI-MS and HRESI-MS. The results of their preliminary cytotoxic activities indicated that compound 7 had significant activity against the MG-63 cell line with an IC50 value of 3.11 μ M, exhibiting a more potent inhibitory effect than adriamycin (IC50 36.31 μ M). Graphical Abstract: ga1 Highlights: Four new cardiac sapogenins were isolated from Periploca forrestii . Their structures were elucidated by NMR spectroscopy and mass spectrometry. Compound 7 showed significant cytotoxicity against the MG-63 cancer cell line.