Nicotinic acetylcholine receptors: Key targets for attenuating neurodegenerative diseases. (April 2023)

• Record Type: Journal Article
• Authors: Bye, Lydia J.; Finol-Urdaneta, Rocio K.; Tae, Han-Shen; Adams, David J.
• Is Part Of: International journal of biochemistry & cell biology. Volume 157(2023)
• Publication Date: 2023-04
• Subjects: α-Bgtx α-bungarotoxin -- 5HT3 5-hydroxytryptamine -- Aβ amyloid beta -- ACh acetylcholine -- AD Alzheimer's disease -- ALS Amyotrophic lateral sclerosis -- ASIC acid-sensing ion channel -- BDNF brain-derived neurotrophic factor -- CAP cholinergic anti-inflammatory pathway -- Cav voltage-gated calcium channel -- CNS central nervous system -- CSF-1 colony stimulating factor 1 -- CTE chronic traumatic encephalopathy -- DAM disease associated microglia -- DAP12 DNAX-activating protein 12 kDa -- ECD extracellular domain -- GABAA γ-aminobutyric acid type A; -- GlyR glycine receptor -- GPCR G protein-coupled receptor -- GTP guanosine triphosphate -- HD Huntington's disease -- IFN interferon -- IGF-1 insulin-like growth factor 1 -- IL interleukin -- Kv voltage-gated potassium channel -- LPS lipopolysaccharide -- MCP1 monocyte chemoattractant protein 1 -- MMP matrix metalloproteinase -- MS multiple sclerosis -- nAChR nicotinic acetylcholine receptor -- Nav voltage-gated sodium channel -- NMDA N-methyl-D-aspartate -- NO nitric oxide -- PAM positive allosteric modulator -- PD Parkinson's disease -- ROS reactive oxygen species -- TGF-β transforming growth factor β -- TM transmembrane -- TNF-α tumour-necrosis factor-α -- TREM2 triggering receptor expressed on myeloid cells 2; Inflammation -- Microglia -- Nicotinic acetylcholine receptor -- Neurodegenerative diseases -- Neuroinflammation; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2023.106387
• Languages: English
• ISSNs: 1357-2725

Abstract

Abstract: Nicotinic acetylcholine receptors (nAChRs) are master regulators of immune functions via the cholinergic anti-inflammatory pathway and are expressed in microglia, the brain's resident immune cells. There is an extensive dialogue between the neurons and the glial cells around them from which microglia are tasked with monitoring, nurturing, and defending their microenvironment. Dysregulation of any of these processes can have devastating and long-lasting consequences involving microglia-mediated neuroinflammation associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, amongst others. Disease-associated microglia acquire a distinguishing phenotype that emphasizes scavenging and defence functions while nurturing and repairing functions become muted. Attempts to resolve this critical imbalance remain a key focus of research. Furthermore, cholinergic modulation of neuroinflammation represents a promising avenue for treatment.