Belief updating in psychosis, depression and anxiety disorders: A systematic review across computational modelling approaches. (April 2023)

• Record Type: Journal Article
• Authors: Gibbs-Dean, Toni; Katthagen, Teresa; Tsenkova, Iveta; Ali, Rubbia; Liang, Xinyi; Spencer, Thomas; Diederen, Kelly
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 147(2023)
• Publication Date: 2023-04
• Subjects: Computational modelling -- Belief-updating -- Transdiagnostic -- Learning -- Prediction-error; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2023.105087
• Languages: English
• ISSNs: 0149-7634

Abstract

Abstract: Alterations in belief updating are proposed to underpin symptoms of psychiatric illness, including psychosis, depression, and anxiety. Key parameters underlying belief updating can be captured using computational modelling techniques, aiding the identification of unique and shared deficits, and improving diagnosis and treatment. We systematically reviewed research that applied computational modelling to probabilistic tasks measuring belief updating in stable and volatile (changing) environments, across clinical and subclinical psychosis (n = 17), anxiety (n = 9), depression (n = 9) and transdiagnostic samples (n = 9). Depression disorders related to abnormal belief updating in response to the valence of rewards, evidenced in both stable and volatile environments. Whereas psychosis and anxiety disorders were associated with difficulties adapting to changing contingencies specifically, indicating an inflexibility and/or insensitivity to environmental volatility. Higher-order learning models revealed additional difficulties in the estimation of overall environmental volatility across psychosis disorders, showing increased updating to irrelevant information. These findings stress the importance of investigating belief updating in transdiagnostic samples, using homogeneous experimental and computational modelling approaches. Highlights: Belief updating deficits may underlie psychosis, anxiety, and depression disorders. Computational modelling supports mechanistic insight into these deficits. A novel synthesis of research reveals overlapping and distinct patterns of deficit. Reward processing was affected in depression irrespective of environment stability. Belief updating under volatility was affected in psychosis and anxiety disorders.