Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications. Issue 4 (April 2023)

• Record Type: Journal Article
• Authors: Zheng, Shanliang; Wang, Xingwen; Zhao, Dong; Liu, Hao; Hu, Ying
• Is Part Of: Trends in cell biology. Volume 33:Issue 4(2023)
• Page Start: 312
• Page End: 323
• Publication Date: 2023-04
• Subjects: calcium homeostasis -- endoplasmic reticulum -- mitochondria -- intra-organelle communication -- oncogene -- tumor suppressor; Cytology -- Periodicals; Cytology -- Research -- Periodicals; 571.6
• DOI: 10.1016/j.tcb.2022.07.004
• Languages: English
• ISSNs: 0962-8924

Abstract

Abstract : Calcium ion (Ca 2+ ) is a ubiquitous and versatile signaling molecule controlling a wide variety of cellular processes, such as proliferation, cell death, migration, and immune response, all fundamental processes essential for the establishment of cancer. In recent decades, the loss of Ca 2+ homeostasis has been considered an important driving force in the initiation and progression of malignant diseases. The primary intracellular Ca 2+ store, the endoplasmic reticulum (ER), plays an essential role in maintaining Ca 2+ homeostasis by coordinating with other organelles and the plasma membrane. Here, we discuss the dysregulation of ER-centered Ca 2+ homeostasis in cancer, summarize Ca 2+ -based anticancer therapeutics, and highlight the significance of furthering our understanding of Ca 2+ homeostasis regulation in cancer. Highlights: The dysregulation of calcium ion (Ca 2+ ) homeostasis is an emerging feature of cancer and plays essential roles in the initiation and progression of malignant diseases. Endoplasmic reticulum, a major intracellular Ca 2+ store, modulates Ca 2+ homeostasis in coordination with other intracellular organelles, such as mitochondria and lysosomes. Cancer cells establish cancer hallmarks by altering the expression and activity of Ca 2+ modulators (Ca 2+ pumps, channels, and exchangers). The cancer-driven events mediated by the activation of oncogenes or inhibition of tumor suppressors are closely associated with key Ca 2+ handling toolkits. Ca 2+ homeostasis has become an attractive target for the development of novel anticancer drugs.