Characterizing the adult exposome in men and women from the general population: Results from the EHES-LUX study. (March 2023)

• Record Type: Journal Article
• Authors: Ruiz-Castell, Maria; Le Coroller, Gwenaëlle; Pexaras, Achilleas; Ciprián, Giovana M.; Fagherazzi, Guy; Bohn, Torsten; Maitre, Léa; Sunyer, Jordi; Appenzeller, Brice M.R.
• Is Part Of: Environment international. Volume 173(2023)
• Publication Date: 2023-03
• Subjects: Exposome -- Pollutants -- Environmental exposures -- Population-based survey -- Hair analyses; PBDE Polybrominated flame retardants -- PCBs Polychlorinated biphenyls -- OCs Organochlorine compounds -- OP Organophosphate -- BDE47 2, 2′, 4, 4′-tetrabromodiphenyl ether -- PCB153 2, 2′, 4, 4′, 5, 5′-Hexachlorobiphenyl -- PCB138 2, 2′, 3, 4, 4′, 5′-Hexachlorobiphenyl -- PCB180 2, 2′, 3, 4, 4′, 5, 5′-Heptachlorobiphenyl -- β-HCH β-Hexachlorocyclohexane -- γ-HCH γ-Hexachlorocyclohexane -- p, p'-DDE 1, 1-dichloro-2, 2-bis(4-chlorophenyl)ethane -- PCP Pentachlorophenol -- 2-ClBA 2-(4-chlorophenyl)-3-methylbutyric acid -- Br2CA Cis-3-(2, 2dibromovinyl)-2, 2-dimethylcyclopropane-carboxylic acid -- Cl2CA Cis-3-(2, 2dichlorovinyl)-2, 2-dimethylcyclopropane-carboxylic acid -- ClCF3CA 3-(2-chloro-3, 3, 3-trifluoro-1-propenyl)-2, 2-dimethylcyclopropanecarboxylic acid -- 4F3PBA 4-fluoro-3-phenoxybenzoic acid -- 3-PBA 3-phenoxybenzoic acid -- IMPy 2-isopropyl-4-methyl-6-hydroxypyrimidine -- DMP Di-methyl-phosphate -- DMTP Di-methyl-thiophosphate -- DMDTP Di-methyl-di-thiophosphate -- DEP Di-ethylphosphate -- DETP Di-ethyl-thiophosphate -- DEDTP Di-ethyl-di-thiophosphate -- TCPy 3, 5, 6-trichloro-2-pyridinol -- PNP P-Nitrophenol -- 3Me4NP 3-methyl-4-nitrophenol -- MCPA 4-chloro-2-methylphenoxyacetic acid -- 2, 4-D 2, 4-dichlorophenoxyacetic acid -- MCPB 4-(4chloro-2-methylphenoxy) butyric acid -- 2, 4-DB 2, 4-dichlorophenoxybutyric acid -- HCB Hexachlorobenzene -- DMST Dimethylsulftoluidide -- BPA Bisphenol A -- BPS Bisphenol S -- GC–MS/MS Gas chromatography-tandem mass spectrometry -- HLCP High Performance Liquid Chromatography; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2023.107780
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Throughout life individuals are exposed to a large array of diverse environmental exposures (exposome). Hair analyses can assess chronic exposure to a large number of chemicals with less intra-variability than urine and blood. This is essential for studies that aim to achieve a global vision of the exposome. We aimed at characterizing the adult exposome by describing 175 environmental exposures and correlation patterns between and within exposure groups. A subsample of participants of the European Health Examination Survey, covering information on exposure to chemical pollutants in hair samples, were included in the present analysis (N = 442). Concentrations of micronutrients, lifestyle, home environment and socioeconomic information completed the exposome description and were obtained through blood analyses and questionnaires. We detected 29 persistent and non-persistent chemical pollutants in more than 70% of hair samples. Compared to women, men had higher concentrations of pesticides, lower concentrations of micronutrients (with the exception of vitamin A), and presented higher alcohol consumption. Across all exposures, a low median absolute correlation was found, 0.05 (5th − 95th centiles = 0.10, 0.20). We observed higher correlations and median correlations within exposure groups than between groups of exposure. The highest median correlation was observed between plasticizers (bisphenol A and S) in both men (0.50) and women (0.31). A 70% and 95% of cumulative variance was explained by 37 and 73 principal components respectively. We found a wide range of chemical exposures in hair samples of men and women. The adult exposome was complex and multidimensional. Future exposome studies should include hair as a matrix for characterizing exposure to multiple environmental chemicals.