Humoral and T-cell responses to SARS-CoV-2 vaccination in patients receiving immunosuppression. Issue 10 (6th August 2021)

• Record Type: Journal Article
• Authors: Prendecki, Maria; Clarke, Candice; Edwards, Helena; McIntyre, Stacey; Mortimer, Paige; Gleeson, Sarah; Martin, Paul; Thomson, Tina; Randell, Paul; Shah, Anand; Singanayagam, Aran; Lightstone, Liz; Cox, Alison; Kelleher, Peter; Willicombe, Michelle; McAdoo, Stephen P
• Is Part Of: Annals of the rheumatic diseases. Volume 80:Issue 10(2021)
• Page Start: 1322
• Page End: 1329
• Publication Date: 2021-08-06
• Subjects: vaccination -- rituximab -- COVID-19 -- B-lymphocytes -- autoimmune diseases; Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2021-220626
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objective: There is an urgent need to assess the impact of immunosuppressive therapies on the immunogenicity and efficacy of SARS-CoV-2 vaccination. Methods: Serological and T-cell ELISpot assays were used to assess the response to first-dose and second-dose SARS-CoV-2 vaccine (with either BNT162b2 mRNA or ChAdOx1 nCoV-19 vaccines) in 140 participants receiving immunosuppression for autoimmune rheumatic and glomerular diseases. Results: Following first-dose vaccine, 28.6% (34/119) of infection-naïve participants seroconverted and 26.0% (13/50) had detectable T-cell responses to SARS-CoV-2. Immune responses were augmented by second-dose vaccine, increasing seroconversion and T-cell response rates to 59.3% (54/91) and 82.6% (38/46), respectively. B-cell depletion at the time of vaccination was associated with failure to seroconvert, and tacrolimus therapy was associated with diminished T-cell responses. Reassuringly, only 8.7% of infection-naïve patients had neither antibody nor T-cell responses detected following second-dose vaccine. In patients with evidence of prior SARS-CoV-2 infection (19/140), all mounted high-titre antibody responses after first-dose vaccine, regardless of immunosuppressive therapy. Conclusion: SARS-CoV-2 vaccines are immunogenic in patients receiving immunosuppression, when assessed by a combination of serology and cell-based assays, although the response is impaired compared with healthy individuals. B-cell depletion following rituximab impairs serological responses, but T-cell responses are preserved in this group. We suggest that repeat vaccine doses for serological non-responders should be investigated as means to induce more robust immunological response.