Association of Circulating Fibrocytes With Fibrostenotic Small Bowel Crohn's Disease. Issue 2 (1st February 2022)

• Record Type: Journal Article
• Authors: Ueno, Aito; Jijon, Humberto B; Peng, Richard; Sparksman, Steven; Mainoli, Barbara; Filyk, Alexis; Li, Yan; Wilson, Stephanie; Novak, Kerri; Panaccione, Remo; Hirota, Simon; Dufour, Antoine; Lu, Cathy; Beck, Paul L
• Is Part Of: Inflammatory bowel diseases. Volume 28:Issue 2(2022)
• Publication Date: 2022-02-01
• Subjects: inflammatory bowel disease -- Crohn's disease -- fibrosis -- fibrogenesis; Inflammatory bowel diseases -- Periodicals; Colitis, Ulcerative -- Periodicals; Crohn Disease -- Periodicals; Inflammatory Bowel Diseases -- Periodicals; 616.344
• DOI: 10.1093/ibd/izab157
• Languages: English
• ISSNs: 1078-0998

Abstract

Abstract : Lay Summary: Intestinal strictures are thought to result from excessive deposition of extracellular matrix by activated mesenchymal cells. In this study, we provide evidence that supports a potential role of fibrocytes (bone marrow–derived mesenchymal precursors) in collagen deposition in Crohn's disease strictures. Inasmuch as fibrocyte numbers correlate with sonographic measures of bowel stiffness, fibrocyte numbers may predict the need for therapy escalation.