Randomized controlled trial of EndoRings assisted colonoscopy versus standard colonoscopy. Issue 3 (27th October 2022)

• Record Type: Journal Article
• Authors: Thayalasekaran, Sreedhari; Bhattacharyya, Rupam; Chedgy, Fergus; Basford, Peter; Subramaniam, Sharmila; Kandiah, Kesavan; Thursby‐Pelham, Fergus; Brown, James; Alkandari, Asma; Ellis, Richard; Coda, Sergio; Goggin, Patrick; Amos, Mark; Fogg, Carole; Longcroft‐Wheaton, Gaius; Bhandari, Pradeep
• Is Part Of: Digestive endoscopy. Volume 35:Issue 3(2023)
• Page Start: 354
• Page End: 360
• Publication Date: 2022-10-27
• Subjects: colonic neoplasm -- colonic polyp -- colonoscopy -- human -- randomized controlled trial; Digestive organs -- Diseases -- Periodicals; Digestive organs -- Diseases -- Diagnosis -- Periodicals; Endoscopy -- Periodicals; Digestive System Diseases -- diagnosis -- Periodicals; Digestive System Diseases -- therapy -- Periodicals; Endoscopy -- Periodicals; 616.3
• DOI: 10.1111/den.14432
• Languages: English
• ISSNs: 0915-5635

Abstract

Abstract : Objectives: The EndoRings device is a distal attachment consisting of two layers of circular flexible rings that evert mucosal folds. The aim of this study was to investigate whether EndoRing assisted colonoscopy (ER) improves polyp and adenoma detection compared to standard colonoscopy (SC). Methods: Multicenter, parallel group, randomized controlled trial. Results: Total of 556 patients randomized to ER ( n = 275) or SC ( n = 281). Colonoscopy completed in 532/556 (96%) cases. EndoRings removed in 74/275 (27%) patients. Total number of polyps in ER limb 582 vs. 515 in SC limb, P = 0.04. Total number of adenomas in ER limb 361 vs. 343 for SC limb, P = 0.49. A statistically significant difference in the mean number of polyps per patient in both the intention to treat (1.84 SC vs. 2.10 ER, P = 0.027) and per protocol (PP) (1.84 SC vs. 2.25 ER, P = 0.004). Conclusions: Our study shows promise for the EndoRings device to improve polyp detection.