The role of receptor‐type protein tyrosine phosphatases in cancer. Issue 1 (2nd January 2023)

• Record Type: Journal Article
• Authors: Lv, Zhengyuan; Wang, Tianming; Cao, Xin; Sun, Mengting; Qu, Yuan
• Is Part Of: Precision medical sciences. Volume 12:Issue 1(2023)
• Page Start: 48
• Page End: 57
• Publication Date: 2023-01-02
• Subjects: cancer -- RPTPs -- reversible phosphorylation; Personalized medicine -- Periodicals; Cancer -- Treatment -- Periodicals; Oncology -- Periodicals; 616.994
• DOI: 10.1002/prm2.12090
• Languages: English
• ISSNs: 2642-2514

Abstract

Abstract: Receptor‐type protein tyrosine phosphatases (RPTPs), Class I protein tyrosine phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of tyrosine residues. This review summarizes the expression and role of RPTPs in cancer and illustrates the signaling pathway mechanisms of effecting oncogenesis, tumor progression, prognosis, and angiogenesis, so as to provide more effective targets for gene therapy of related cancers. Abstract : RPTPs can be divided into eight subfamilies named R1/R6, R2A, R2B, R3, R4, R5, R7, and R8. They function to regulate distinct signaling pathways related to cancer through the reversible phosphorylation of tyrosine residues and are potential targets for cancer therapy.