Wnt signalling in the articular cartilage: A matter of balance. Issue 2 (26th February 2023)

• Record Type: Journal Article
• Authors: Gill, Amandeep Kaur; McCormick, Peter J.; Sochart, David; Nalesso, Giovanna
• Is Part Of: International journal of experimental pathology. Volume 104:Issue 2(2023)
• Page Start: 56
• Page End: 63
• Publication Date: 2023-02-26
• Subjects: articular cartilage -- osteoarthritis -- Wnt; Pathology, Experimental -- Periodicals; 616.07
• DOI: 10.1111/iep.12472
• Languages: English
• ISSNs: 0959-9673

Abstract

Abstract: Degradation of the articular cartilage is a hallmark of osteoarthritis, a progressive and chronic musculoskeletal condition, affecting millions of people worldwide. The activation of several signalling cascades is altered during disease development: among them, the Wnt signalling plays a pivotal role in the maintenance of tissue homeostasis. Increasing evidence is showing that its activation needs to be maintained within a certain range to avoid the triggering of degenerative mechanisms. In this review, we summarise our current knowledge about how a balanced activation of the Wnt signalling is maintained in the articular cartilage, with a particular focus on receptor‐mediated mechanisms.